Description: Homo sapiens calmodulin 1 (phosphorylase kinase, delta) (CALM1), mRNA. RefSeq Summary (NM_006888): This gene encodes one of three calmodulin proteins which are members of the EF-hand calcium-binding protein family. Calcium-induced activation of calmodulin regulates and modulates the function of cardiac ion channels. Two pseudogenes have been identified on chromosome 7 and X. Multiple transcript variants encoding different isoforms have been found for this gene.A missense mutation in the CALM1 gene has been associated with ventricular tachycardia.[provided by RefSeq, May 2020]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Transcript (Including UTRs) Position: hg19 chr14:90,863,327-90,874,619 Size: 11,293 Total Exon Count: 6 Strand: + Coding Region Position: hg19 chr14:90,863,575-90,871,061 Size: 7,487 Coding Exon Count: 6
ID:CALM_HUMAN DESCRIPTION: RecName: Full=Calmodulin; Short=CaM; FUNCTION: Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CEP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. SUBUNIT: Interacts with MYO1C and RRAD. Interacts with MYO10 (By similarity). Interacts with CEP97, CEP110, TTN/titin and SRY. Interacts with USP6; the interaction is calcium dependent. Interacts with CDK5RAP2. Interacts with SCN5A. Interacts with RYR1 and RYR2. Interacts with FCHO1. INTERACTION: P29274:ADORA2A; NbExp=3; IntAct=EBI-397435, EBI-2902702; P49407:ARRB1; NbExp=3; IntAct=EBI-397435, EBI-743313; P32121:ARRB2; NbExp=3; IntAct=EBI-397435, EBI-714559; Q13936:CACNA1C; NbExp=2; IntAct=EBI-397435, EBI-1038838; O43303:CCP110; NbExp=9; IntAct=EBI-397435, EBI-1566217; P40136:cya (xeno); NbExp=8; IntAct=EBI-397435, EBI-457011; P00533:EGFR; NbExp=3; IntAct=EBI-397435, EBI-297353; P25445:FAS; NbExp=4; IntAct=EBI-397435, EBI-494743; O95259:KCNH1; NbExp=2; IntAct=EBI-397435, EBI-2909270; P26645:Marcks (xeno); NbExp=2; IntAct=EBI-397435, EBI-911805; Q14524:SCN5A; NbExp=2; IntAct=EBI-397435, EBI-726858; SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules. PTM: Ubiquitination results in a strongly decreased activity (By similarity). PTM: Phosphorylation results in a decreased activity (By similarity). MISCELLANEOUS: This protein has four functional calcium-binding sites. SIMILARITY: Belongs to the calmodulin family. SIMILARITY: Contains 4 EF-hand domains. SEQUENCE CAUTION: Sequence=CAA36839.1; Type=Erroneous gene model prediction; WEB RESOURCE: Name=Protein Spotlight; Note=A question of length - Issue 105 of May 2009; URL="http://web.expasy.org/spotlight/back_issues/sptlt105.shtml";
osteoarthritis Mototani, H. et al. 2005, A functional single nucleotide polymorphism in the core promoter region of CALM1 is associated with hip osteoarthritis in Japanese., Human molecular genetics. 2005 Apr;14(8):1009-17.
[PubMed 15746150]
These results suggest that the transcriptional level of CALM1 is associated with susceptibility for hip OA through modulation of chondrogenic activity. Our findings reveal the CALM1-mediated signaling pathway in chondrocytes as a novel potential target for treatment of OA.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00036 - EF hand PF08726 - Ca2+ insensitive EF hand PF12763 - Cytoskeletal-regulatory complex EF hand PF13202 - EF hand PF13405 - EF-hand domain PF13499 - EF-hand domain pair PF13833 - EF-hand domain pair PF14658 - EF-hand domain
ModBase Predicted Comparative 3D Structure on P62158
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Descriptions from all associated GenBank mRNAs
JC051453 - Sequence 5 from Patent WO2013153214. JC051457 - Sequence 9 from Patent WO2013153214. JC051460 - Sequence 12 from Patent WO2013153214. BC011834 - Homo sapiens calmodulin 1 (phosphorylase kinase, delta), mRNA (cDNA clone MGC:20018 IMAGE:3942245), complete cds. BC047523 - Homo sapiens calmodulin 1 (phosphorylase kinase, delta), mRNA (cDNA clone IMAGE:4819353). AH005375 - Homo sapiens Human calmodulin-I (CALM1) mRNA, 5'UTR, partial sequence. BC000454 - Homo sapiens calmodulin 1 (phosphorylase kinase, delta), mRNA (cDNA clone MGC:8460 IMAGE:2821489), complete cds. BC008597 - Homo sapiens calmodulin 1 (phosphorylase kinase, delta), mRNA (cDNA clone MGC:17489 IMAGE:3452971), complete cds. AK289937 - Homo sapiens cDNA FLJ75174 complete cds, highly similar to Homo sapiens calmodulin 1 (phosphorylase kinase, delta), mRNA. M27319 - Human calmodulin mRNA, complete cds. L37715 - Homo sapiens (clone 22) macronuclear mRNA. JD187146 - Sequence 168170 from Patent EP1572962. JD466811 - Sequence 447835 from Patent EP1572962. AY189287 - Homo sapiens LP7057 protein mRNA, complete cds. BC007965 - Homo sapiens calmodulin 1 (phosphorylase kinase, delta), mRNA (cDNA clone MGC:14464 IMAGE:4308380), complete cds. BT006818 - Homo sapiens calmodulin 1 (phosphorylase kinase, delta) mRNA, complete cds. KJ896533 - Synthetic construct Homo sapiens clone ccsbBroadEn_05927 CALM1 gene, encodes complete protein. KJ905153 - Synthetic construct Homo sapiens clone ccsbBroadEn_14558 CALM1 gene, encodes complete protein. KJ904427 - Synthetic construct Homo sapiens clone ccsbBroadEn_13821 CALM1 gene, encodes complete protein. JD097116 - Sequence 78140 from Patent EP1572962. BX537677 - Homo sapiens mRNA; cDNA DKFZp686K05204 (from clone DKFZp686K05204). DL491437 - Novel nucleic acids. DL490058 - Novel nucleic acids. JD360025 - Sequence 341049 from Patent EP1572962. JD341250 - Sequence 322274 from Patent EP1572962. BX648223 - Homo sapiens mRNA; cDNA DKFZp779O0624 (from clone DKFZp779O0624). JD566375 - Sequence 547399 from Patent EP1572962. JD042486 - Sequence 23510 from Patent EP1572962. JD352155 - Sequence 333179 from Patent EP1572962. JD469806 - Sequence 450830 from Patent EP1572962. JD044779 - Sequence 25803 from Patent EP1572962. JD496726 - Sequence 477750 from Patent EP1572962. JD231650 - Sequence 212674 from Patent EP1572962. JD528541 - Sequence 509565 from Patent EP1572962. JD236021 - Sequence 217045 from Patent EP1572962. JD521599 - Sequence 502623 from Patent EP1572962. JD379074 - Sequence 360098 from Patent EP1572962. JD499261 - Sequence 480285 from Patent EP1572962. JD190122 - Sequence 171146 from Patent EP1572962. JD382631 - Sequence 363655 from Patent EP1572962. JD231440 - Sequence 212464 from Patent EP1572962. JD492420 - Sequence 473444 from Patent EP1572962. JD204696 - Sequence 185720 from Patent EP1572962. JD227408 - Sequence 208432 from Patent EP1572962. JD038832 - Sequence 19856 from Patent EP1572962. JD235715 - Sequence 216739 from Patent EP1572962. JD245259 - Sequence 226283 from Patent EP1572962. JD038095 - Sequence 19119 from Patent EP1572962. JD193728 - Sequence 174752 from Patent EP1572962. JD243808 - Sequence 224832 from Patent EP1572962. JD328281 - Sequence 309305 from Patent EP1572962. JD434418 - Sequence 415442 from Patent EP1572962. JD126366 - Sequence 107390 from Patent EP1572962. JD109870 - Sequence 90894 from Patent EP1572962. JD264245 - Sequence 245269 from Patent EP1572962. JD082393 - Sequence 63417 from Patent EP1572962. BC042831 - Homo sapiens calmodulin 1 (phosphorylase kinase, delta), mRNA (cDNA clone IMAGE:5301034). JD201994 - Sequence 183018 from Patent EP1572962. JD026942 - Sequence 7966 from Patent EP1572962. JD029032 - Sequence 10056 from Patent EP1572962. JD374934 - Sequence 355958 from Patent EP1572962. JD279983 - Sequence 261007 from Patent EP1572962. JD495556 - Sequence 476580 from Patent EP1572962. JD494334 - Sequence 475358 from Patent EP1572962.
BioCarta from NCI Cancer Genome Anatomy Project h_At1rPathway - Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling h_fMLPpathway - fMLP induced chemokine gene expression in HMC-1 cells h_gpcrPathway - Signaling Pathway from G-Protein Families h_nfatPathway - NFAT and Hypertrophy of the heart (Transcription in the broken heart) h_pyk2Pathway - Links between Pyk2 and Map Kinases h_Ccr5Pathway - Pertussis toxin-insensitive CCR5 Signaling in Macrophage h_gcrPathway - Corticosteroids and cardioprotection h_no1Pathway - Actions of Nitric Oxide in the Heart h_mef2dPathway - Role of MEF2D in T-cell Apoptosis h_biopeptidesPathway - Bioactive Peptide Induced Signaling Pathway h_nos1Pathway - Nitric Oxide Signaling Pathway h_pgc1aPathway - Regulation of PGC-1a h_vipPathway - Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells h_tcrPathway - T Cell Receptor Signaling Pathway h_bcrPathway - BCR Signaling Pathway h_calcineurinPathway - Effects of calcineurin in Keratinocyte Differentiation h_ndkDynaminPathway - Endocytotic role of NDK, Phosphins and Dynamin h_CaCaMPathway - Ca++/ Calmodulin-dependent Protein Kinase Activation h_fcer1Pathway - Fc Epsilon Receptor I Signaling in Mast Cells h_hdacPathway - Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK)
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