To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): CRTC1 CDC HuGE Published Literature: CRTC1 Positive Disease Associations: Menarche Related Studies:
Menarche Cathy E Elks et al. Nature genetics 2010, Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies., Nature genetics.
[PubMed 21102462]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF12884 - Transducer of regulated CREB activity, N terminus PF12885 - Transducer of regulated CREB activity middle domain PF12886 - Transducer of regulated CREB activity, C terminus
ModBase Predicted Comparative 3D Structure on Q6UUV9-2
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
