Description: Homo sapiens colony stimulating factor 1 (macrophage) (CSF1), transcript variant 1, mRNA. RefSeq Summary (NM_000757): The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. The encoded protein may be involved in development of the placenta. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]. Transcript (Including UTRs) Position: hg19 chr1:110,453,233-110,473,616 Size: 20,384 Total Exon Count: 9 Strand: + Coding Region Position: hg19 chr1:110,453,646-110,467,811 Size: 14,166 Coding Exon Count: 8
ID:CSF1_HUMAN DESCRIPTION: RecName: Full=Macrophage colony-stimulating factor 1; Short=CSF-1; Short=M-CSF; Short=MCSF; AltName: Full=Lanimostim; Contains: RecName: Full=Processed macrophage colony-stimulating factor 1; Flags: Precursor; FUNCTION: Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. SUBUNIT: Homodimer or heterodimer; disulfide-linked. Interacts with CSF1R. SUBCELLULAR LOCATION: Cell membrane; Single-pass membrane protein. SUBCELLULAR LOCATION: Processed macrophage colony-stimulating factor 1: Secreted, extracellular space. PTM: N- and O-glycosylated. Glycosylation and proteolytic cleavage yield different soluble forms. One high molecular weight soluble form is a proteoglycan containing chondroitin sulfate. O- glycosylated with core 1 or possibly core 8 glycans. Isoform 1 is N- and O-glycosylated. Isoform 3 is only N-glycosylated. DISEASE: Note=Aberrant expression of CSF1 or CSF1R can promote cancer cell proliferation, invasion and formation of metastases. Overexpression of CSF1 or CSF1R is observed in a significant percentage of breast, ovarian, prostate, and endometrial cancers. DISEASE: Note=Aberrant expression of CSF1 or CSF1R may play a role in inflammatory diseases, such as rheumatoid arthritis, glomerulonephritis, atherosclerosis, and allograft rejection.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P09603
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
LF211919 - JP 2014500723-A/19422: Polycomb-Associated Non-Coding RNAs. LF206295 - JP 2014500723-A/13798: Polycomb-Associated Non-Coding RNAs. LF353045 - JP 2014500723-A/160548: Polycomb-Associated Non-Coding RNAs. BC021117 - Homo sapiens colony stimulating factor 1 (macrophage), mRNA (cDNA clone MGC:31930 IMAGE:4586312), complete cds. E03219 - DNA encoding human M-CSF(macrophage colony stimulating factor). E03235 - cDNA encoding human M-CSF. AK291660 - Homo sapiens cDNA FLJ75722 complete cds, highly similar to Homo sapiens colony stimulating factor 1 (CSF1), transcript variant 1, mRNA. AB208952 - Homo sapiens mRNA for colony stimulating factor 1 isoform a precursor variant protein. M37435 - Human macrophage-specific colony-stimulating factor (CSF-1) mRNA, complete cds. M27087 - Homo sapiens macrophage colony-stimulating factor (M-CSF1) cDNA to mRNA, complete cds. E01949 - cDNA encoding human M-CSF. E01950 - cDNA encoding human M-CSF. E02182 - DNA encoding human M-CSF (colony Stimulating factor). E02183 - DNA encoding human M-CSF (colony Stimulating factor). E09614 - Human cDNA encoding M-CSF. E09615 - Human cDNA encoding M-CSF. JD395963 - Sequence 376987 from Patent EP1572962. U22386 - Human macrophage-colony stimulating factor gamma precursor mRNA, complete cds. AB527768 - Synthetic construct DNA, clone: pF1KB9973, Homo sapiens CSF1 gene for colony stimulating factor 1, without stop codon, in Flexi system. KJ896655 - Synthetic construct Homo sapiens clone ccsbBroadEn_06049 CSF1 gene, encodes complete protein. KR710585 - Synthetic construct Homo sapiens clone CCSBHm_00014149 CSF1 (CSF1) mRNA, encodes complete protein. M64592 - Human macrophage colony stimulating factor (M-CSF-1) mRNA, complete cds. M76453 - Homo sapiens colony stimulating factor 1 (CSF1) mRNA, partial cds. X05825 - Human mRNA for colony stimulating factor CSF-4. JF803735 - Homo sapiens macrophage colony-stimulating factor 1 mRNA, partial cds. E02184 - DNA encoding human M-CSF. E02185 - DNA encoding human M-CSF. E02187 - DNA encoding human M-CSF. E02188 - DNA encoding human M-CSF. E02186 - DNA encoding human M-CSF. E02189 - DNA encoding human M-CSF. AK300401 - Homo sapiens cDNA FLJ60891 complete cds, highly similar to Macrophage colony-stimulating factor 1 precursor. LF353041 - JP 2014500723-A/160544: Polycomb-Associated Non-Coding RNAs. AK311440 - Homo sapiens cDNA, FLJ18482. LF353039 - JP 2014500723-A/160542: Polycomb-Associated Non-Coding RNAs. LF353038 - JP 2014500723-A/160541: Polycomb-Associated Non-Coding RNAs. LF353037 - JP 2014500723-A/160540: Polycomb-Associated Non-Coding RNAs. LF353036 - JP 2014500723-A/160539: Polycomb-Associated Non-Coding RNAs. LF353035 - JP 2014500723-A/160538: Polycomb-Associated Non-Coding RNAs. LF353034 - JP 2014500723-A/160537: Polycomb-Associated Non-Coding RNAs. JD204702 - Sequence 185726 from Patent EP1572962. JD393180 - Sequence 374204 from Patent EP1572962. JD464305 - Sequence 445329 from Patent EP1572962. JD163723 - Sequence 144747 from Patent EP1572962. JD140743 - Sequence 121767 from Patent EP1572962. JD193404 - Sequence 174428 from Patent EP1572962. JD157738 - Sequence 138762 from Patent EP1572962. JD173073 - Sequence 154097 from Patent EP1572962. JD493861 - Sequence 474885 from Patent EP1572962. JD157450 - Sequence 138474 from Patent EP1572962. JD270994 - Sequence 252018 from Patent EP1572962. JD372740 - Sequence 353764 from Patent EP1572962. JD182431 - Sequence 163455 from Patent EP1572962. JD067909 - Sequence 48933 from Patent EP1572962. LF353030 - JP 2014500723-A/160533: Polycomb-Associated Non-Coding RNAs. JD382550 - Sequence 363574 from Patent EP1572962. JD373260 - Sequence 354284 from Patent EP1572962. JD208916 - Sequence 189940 from Patent EP1572962. JD361276 - Sequence 342300 from Patent EP1572962. JD148154 - Sequence 129178 from Patent EP1572962. LF353029 - JP 2014500723-A/160532: Polycomb-Associated Non-Coding RNAs. JD060919 - Sequence 41943 from Patent EP1572962. JD396541 - Sequence 377565 from Patent EP1572962. LF353028 - JP 2014500723-A/160531: Polycomb-Associated Non-Coding RNAs. LF353027 - JP 2014500723-A/160530: Polycomb-Associated Non-Coding RNAs. LF353026 - JP 2014500723-A/160529: Polycomb-Associated Non-Coding RNAs. LF353025 - JP 2014500723-A/160528: Polycomb-Associated Non-Coding RNAs. MA588622 - JP 2018138019-A/160548: Polycomb-Associated Non-Coding RNAs. MA588618 - JP 2018138019-A/160544: Polycomb-Associated Non-Coding RNAs. MA588616 - JP 2018138019-A/160542: Polycomb-Associated Non-Coding RNAs. MA588615 - JP 2018138019-A/160541: Polycomb-Associated Non-Coding RNAs. MA588614 - JP 2018138019-A/160540: Polycomb-Associated Non-Coding RNAs. MA588613 - JP 2018138019-A/160539: Polycomb-Associated Non-Coding RNAs. MA588612 - JP 2018138019-A/160538: Polycomb-Associated Non-Coding RNAs. MA588611 - JP 2018138019-A/160537: Polycomb-Associated Non-Coding RNAs. MA588607 - JP 2018138019-A/160533: Polycomb-Associated Non-Coding RNAs. MA588606 - JP 2018138019-A/160532: Polycomb-Associated Non-Coding RNAs. MA588605 - JP 2018138019-A/160531: Polycomb-Associated Non-Coding RNAs. MA588604 - JP 2018138019-A/160530: Polycomb-Associated Non-Coding RNAs. MA588603 - JP 2018138019-A/160529: Polycomb-Associated Non-Coding RNAs. MA588602 - JP 2018138019-A/160528: Polycomb-Associated Non-Coding RNAs. MA447496 - JP 2018138019-A/19422: Polycomb-Associated Non-Coding RNAs. MA441872 - JP 2018138019-A/13798: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04060 - Cytokine-cytokine receptor interaction hsa04640 - Hematopoietic cell lineage
BioCarta from NCI Cancer Genome Anatomy Project h_stemPathway - Regulation of hematopoiesis by cytokines h_LDLpathway - Low-density lipoprotein (LDL) pathway during atherogenesis h_inflamPathway - Cytokines and Inflammatory Response h_etsPathway - METS affect on Macrophage Differentiation h_mspPathway - Msp/Ron Receptor Signaling Pathway
Reactome (by CSHL, EBI, and GO)
Protein P09603 (Reactome details) participates in the following event(s):
R-HSA-9009488 IL34 binds CSF1 R-HSA-8952289 FAM20C phosphorylates FAM20C substrates R-HSA-449836 Other interleukin signaling R-HSA-6783783 Interleukin-10 signaling R-HSA-449147 Signaling by Interleukins R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275 Post-translational protein phosphorylation R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-392499 Metabolism of proteins R-HSA-597592 Post-translational protein modification R-HSA-168256 Immune System