Human Gene FKBP7 (uc002umk.3) Description and Page Index
  Description: Homo sapiens FK506 binding protein 7 (FKBP7), transcript variant 1, mRNA.
RefSeq Summary (NM_181342): The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase (PPIase) family. Members of this family exhibit PPIase activity and function as molecular chaperones. A similar protein in mouse is located in the endoplasmic reticulum and binds calcium. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: hg19 chr2:179,328,391-179,343,355 Size: 14,965 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr2:179,330,497-179,343,226 Size: 12,730 Coding Exon Count: 4 

Page IndexSequence and LinksGenetic AssociationsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:179,328,391-179,343,355)mRNA (may differ from genome)Protein (222 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCLynxMGIOMIM
PubMedStanford SOURCEUniProtKB

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): FKBP7
CDC HuGE Published Literature: FKBP7
Positive Disease Associations: Cholesterol, LDL
Related Studies:
  1. Cholesterol, LDL
    , , . [PubMed 0]

-  MalaCards Disease Associations
  MalaCards Gene Search: FKBP7
Diseases sorted by gene-association score: osteogenesis imperfecta, type ix (5)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 16.85 RPKM in Ovary
Total median expression: 193.41 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -60.00129-0.465 Picture PostScript Text
3' UTR -466.002106-0.221 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00254 - FKBP-type peptidyl-prolyl cis-trans isomerase
PF13202 - EF hand
PF13499 - EF-hand domain pair

SCOP Domains:
47473 - EF-hand
54534 - FKBP-like

ModBase Predicted Comparative 3D Structure on Q9Y680-2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Descriptions from all associated GenBank mRNAs
  KJ893965 - Synthetic construct Homo sapiens clone ccsbBroadEn_03359 FKBP7 gene, encodes complete protein.
AK292145 - Homo sapiens cDNA FLJ75898 complete cds, highly similar to Homo sapiens FK506 binding protein 7 (FKBP7), transcript variant 2, mRNA.
AK299215 - Homo sapiens cDNA FLJ57571 complete cds, highly similar to FK506-binding protein 7 precursor (EC 5.2.1.8).
AF092137 - Homo sapiens FK506-binding protein mRNA, complete cds.
JD063508 - Sequence 44532 from Patent EP1572962.
AY359015 - Homo sapiens clone DNA65406 FKBP (UNQ670) mRNA, complete cds.
BC009711 - Homo sapiens FK506 binding protein 7, mRNA (cDNA clone MGC:9420 IMAGE:3891173), complete cds.
AF100751 - Homo sapiens FK506-binding protein FKB23 isoform mRNA, complete cds.
LF205736 - JP 2014500723-A/13239: Polycomb-Associated Non-Coding RNAs.
AY353086 - Homo sapiens FK506-binding protein 7 (FKBP7) mRNA, complete cds; alternatively spliced.
BT007122 - Homo sapiens FK506 binding protein 7 mRNA, complete cds.
EU831809 - Synthetic construct Homo sapiens clone HAIB:100066838; DKFZo008F0521 FK506 binding protein 7 protein (FKBP7) gene, encodes complete protein.
EU831886 - Synthetic construct Homo sapiens clone HAIB:100066915; DKFZo004F0522 FK506 binding protein 7 protein (FKBP7) gene, encodes complete protein.
LF347603 - JP 2014500723-A/155106: Polycomb-Associated Non-Coding RNAs.
CU679453 - Synthetic construct Homo sapiens gateway clone IMAGE:100016802 5' read FKBP7 mRNA.
LF347604 - JP 2014500723-A/155107: Polycomb-Associated Non-Coding RNAs.
LF347605 - JP 2014500723-A/155108: Polycomb-Associated Non-Coding RNAs.
LF347606 - JP 2014500723-A/155109: Polycomb-Associated Non-Coding RNAs.
LF347608 - JP 2014500723-A/155111: Polycomb-Associated Non-Coding RNAs.
LF347610 - JP 2014500723-A/155113: Polycomb-Associated Non-Coding RNAs.
JD051364 - Sequence 32388 from Patent EP1572962.
MA583180 - JP 2018138019-A/155106: Polycomb-Associated Non-Coding RNAs.
MA583181 - JP 2018138019-A/155107: Polycomb-Associated Non-Coding RNAs.
MA583182 - JP 2018138019-A/155108: Polycomb-Associated Non-Coding RNAs.
MA583183 - JP 2018138019-A/155109: Polycomb-Associated Non-Coding RNAs.
MA583185 - JP 2018138019-A/155111: Polycomb-Associated Non-Coding RNAs.
MA583187 - JP 2018138019-A/155113: Polycomb-Associated Non-Coding RNAs.
MA441313 - JP 2018138019-A/13239: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: FKBP23, NM_181342, NP_851939, Q9Y680-2, UNQ670/PRO1304
UCSC ID: uc002umk.3
RefSeq Accession: NM_181342
Protein: Q9Y680-2, splice isoform of Q9Y680 CCDS: CCDS2280.1, CCDS46462.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_181342.2
exon count: 4CDS single in 3' UTR: no RNA size: 2904
ORF size: 669CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1421.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.