Human Gene ADGRV1 (uc003kjt.4)
  Description: Homo sapiens G protein-coupled receptor 98 (ADGRV1), transcript variant 2, non-coding RNA.
RefSeq Summary (NR_003149): This gene encodes a member of the G-protein coupled receptor superfamily. The encoded protein contains a 7-transmembrane receptor domain, binds calcium and is expressed in the central nervous system. Mutations in this gene are associated with Usher syndrome 2 and familial febrile seizures. Several alternatively spliced transcripts have been described. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: hg19 chr5:89,854,617-90,460,033 Size: 605,417 Total Exon Count: 90 Strand: +


Page IndexSequence and LinksPrimersMalaCardsRNA-Seq ExpressionMicroarray Expression
Other SpeciesmRNA DescriptionsOther NamesGeneReviewsModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:89,854,617-90,460,033)mRNA (may differ from genome)No protein
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
EnsemblExonPrimerH-INVLynxMalacardsPubMed
Wikipedia

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ADGRV1
Diseases sorted by gene-association score: usher syndrome, type 2c* (1327), febrile seizures, familial, 4* (1069), usher syndrome type 2* (224), usher syndrome (30), cervical neuroblastoma (16), extracranial neuroblastoma (16), febrile seizures (15), deafness, autosomal recessive 6 (12), generalized epilepsy with febrile seizures plus* (11), extragonadal seminoma (9), deafness, autosomal recessive 98 (8), usher syndrome, type 2d (8), usher syndrome, type 3a (7), usher syndrome, type 1b (7), usher syndrome, type 1d (6), clear cell ependymoma (6), retinitis pigmentosa (3), nonsyndromic deafness (1)
* = Manually curated disease association

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 29.00 RPKM in Adrenal Gland
Total median expression: 80.39 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  AF435925 - Homo sapiens very large G protein-coupled receptor 1b (VLGR1) mRNA, complete cds.
AF055084 - Homo sapiens very large G-protein coupled receptor-1 (VLGR1) mRNA, complete cds.
AK024416 - Homo sapiens cDNA FLJ14354 fis, clone Y79AA1001384, highly similar to Monogenic audiogenic seizure susceptibility protein 1 homolog precursor.
AB014586 - Homo sapiens mRNA for KIAA0686 protein, partial cds.
BC172212 - Synthetic construct Homo sapiens clone IMAGE:9094358 G protein-coupled receptor 98 precursor (GPR98) gene, partial cds.
BC172199 - Synthetic construct Homo sapiens clone IMAGE:9094289 G protein-coupled receptor 98 precursor (GPR98) gene, partial cds.
BC172219 - Synthetic construct Homo sapiens clone IMAGE:9094300 G protein-coupled receptor 98 precursor (GPR98) gene, partial cds.
AL136541 - Homo sapiens mRNA; cDNA DKFZp761P0710 (from clone DKFZp761P0710).
BC172210 - Synthetic construct Homo sapiens clone IMAGE:9094354 G protein-coupled receptor 98 precursor (GPR98) gene, partial cds.
BC034748 - Homo sapiens G protein-coupled receptor 98, mRNA (cDNA clone IMAGE:5183306), with apparent retained intron.
JD206042 - Sequence 187066 from Patent EP1572962.
BC172200 - Synthetic construct Homo sapiens clone IMAGE:9094290 G protein-coupled receptor 98 precursor (GPR98) gene, partial cds.
AB075823 - Homo sapiens mRNA for KIAA1943 protein.
AL133041 - Homo sapiens mRNA; cDNA DKFZp434L2050 (from clone DKFZp434L2050).
BC172211 - Synthetic construct Homo sapiens clone IMAGE:9094356 G protein-coupled receptor 98 precursor (GPR98) gene, partial cds.
JD288327 - Sequence 269351 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: GPR98, NR_003149, uc003kjt.3
UCSC ID: uc003kjt.4
RefSeq Accession: NR_003149

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene ADGRV1:
usher2 (Usher Syndrome Type II)

-  Gene Model Information
 
category: nearCoding nonsense-mediated-decay: yes RNA accession: NR_003149.1
exon count: 90CDS single in 3' UTR: no RNA size: 19250
ORF size: 0CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 13341.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.