Human Gene IFI27 (uc021sba.1)
  Description: Homo sapiens interferon, alpha-inducible protein 27 (IFI27), transcript variant 2, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr14:94,577,079-94,583,033 Size: 5,955 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr14:94,578,029-94,582,864 Size: 4,836 Coding Exon Count: 4 

Page IndexSequence and LinksPrimersGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:94,577,079-94,583,033)mRNA (may differ from genome)Protein (122 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCLynxMalacardsMGIOMIM
PubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): IFI27
CDC HuGE Published Literature: IFI27

-  MalaCards Disease Associations
  MalaCards Gene Search: IFI27
Diseases sorted by gene-association score: lung clear cell carcinoma (5), esophageal cancer (3), colorectal cancer (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 132.92 RPKM in Spleen
Total median expression: 1341.78 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -35.30123-0.287 Picture PostScript Text
3' UTR -38.80169-0.230 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009311 - Interferon-induced_6-16

Pfam Domains:
PF06140 - Interferon-induced 6-16 family

ModBase Predicted Comparative 3D Structure on A8K0H0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
 Gene Details    
 Gene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  LF384883 - JP 2014500723-A/192386: Polycomb-Associated Non-Coding RNAs.
AK289535 - Homo sapiens cDNA FLJ78595 complete cds, highly similar to Homo sapiens interferon, alpha-inducible protein 27 (IFI27), mRNA.
AK097084 - Homo sapiens cDNA FLJ39765 fis, clone SPLEN2000222.
AK312089 - Homo sapiens cDNA, FLJ92370, highly similar to Homo sapiens interferon, alpha-inducible protein 27 (IFI27), mRNA.
BX647330 - Homo sapiens mRNA; cDNA DKFZp686F05171 (from clone DKFZp686F05171).
AJ294851 - Homo sapiens partial mRNA for ISG12 protein (p27 gene).
AY126456 - Homo sapiens interferon-induced ISG12c delta isoform (ISG12) mRNA, partial cds; alternatively spliced.
AY126457 - Homo sapiens interferon-induced ISG12-S short isoform (ISG12) mRNA, partial cds; alternatively spliced.
AY126458 - Homo sapiens interferon-induced ISG12-S short isoform (ISG12) mRNA, partial cds; alternatively spliced.
BC015492 - Homo sapiens interferon, alpha-inducible protein 27, mRNA (cDNA clone MGC:8967 IMAGE:3915505), complete cds.
X67325 - Homo sapiens mRNA for ISG12 protein.
KJ891426 - Synthetic construct Homo sapiens clone ccsbBroadEn_00820 IFI27 gene, encodes complete protein.
AB463793 - Synthetic construct DNA, clone: pF1KB8359, Homo sapiens IFI27 gene for interferon, alpha-inducible protein 27, without stop codon, in Flexi system.
AM393107 - Synthetic construct Homo sapiens clone IMAGE:100002549 for hypothetical protein (IFI27 gene).
AM393779 - Synthetic construct Homo sapiens clone IMAGE:100002567 for hypothetical protein (IFI27 gene).
DQ893816 - Synthetic construct Homo sapiens clone IMAGE:100008276; FLH164681.01L; RZPDo839A08157D interferon, alpha-inducible protein 27 (IFI27) gene, encodes complete protein.
BT006781 - Homo sapiens interferon, alpha-inducible protein 27 mRNA, complete cds.
LC420312 - Homo sapiens IFI27 mRNA for interferon alpha-inducible protein 27, complete cds.
AK095039 - Homo sapiens cDNA FLJ37720 fis, clone BRHIP2019149, moderately similar to Interferon, alpha-inducible protein 27.
JD151797 - Sequence 132821 from Patent EP1572962.
JD323154 - Sequence 304178 from Patent EP1572962.
MA620460 - JP 2018138019-A/192386: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K0H0, A8K0H0_HUMAN, hCG_22330, NM_001130080, NP_001123552
UCSC ID: uc021sba.1
RefSeq Accession: NM_001130080
Protein: A8K0H0 CCDS: CCDS32148.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001130080.1
exon count: 5CDS single in 3' UTR: no RNA size: 665
ORF size: 360CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 920.00frame shift in genome: no % Coverage: 97.44
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.