Description: Homo sapiens interferon, alpha 2 (IFNA2), mRNA. RefSeq Summary (NM_000605): This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded protein is a cytokine produced in response to viral infection. Use of the recombinant form of this protein has been shown to be effective in reducing the symptoms and duration of the common cold. [provided by RefSeq, Jun 2011]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and experimental data. Transcript (Including UTRs) Position: hg19 chr9:21,384,254-21,385,396 Size: 1,143 Total Exon Count: 1 Strand: - Coding Region Position: hg19 chr9:21,384,762-21,385,328 Size: 567 Coding Exon Count: 1
To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): IFNA2 CDC HuGE Published Literature: IFNA2 Positive Disease Associations: hepatitis B Related Studies:
hepatitis B Song, L. H. et al. 2006, A promoter polymorphism in the interferon alpha-2 gene is associated with the clinical presentation of hepatitis B, Mutat Res 2006.
[PubMed 16920161]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6DJX8
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Descriptions from all associated GenBank mRNAs
KJ891428 - Synthetic construct Homo sapiens clone ccsbBroadEn_00822 IFNA2 gene, encodes complete protein. E00099 - DNA coding of interferon(HLyc IFN-4(1)). E00172 - cDNA encoding human interferon-1(1). JD268229 - Sequence 249253 from Patent EP1572962. M54886 - Human interferon-alpha mRNA, complete cds. V00544 - Messenger RNA for human leukocyte interferon. E00032 - DNA coding of human leukocyte interferon A(LeIF A). E00043 - DNA coding of LeIF A. E00471 - Human leukocyte interferon A (LeIF A) gene and its flanking sequence. E00473 - Human leukocyte interferon A (LeIFA) gene and its flanking sequence. V00549 - Messenger RNA for human leukocyte (alpha) interferon. V00548 - Homo sapiens partial mRNA for interferon alpha-2 precursor (IFNA2 gene). BC104163 - Homo sapiens interferon, alpha 2, mRNA (cDNA clone MGC:125764 IMAGE:40029595), complete cds. BC104164 - Homo sapiens interferon, alpha 2, mRNA (cDNA clone MGC:125765 IMAGE:40029596), complete cds. JD093652 - Sequence 74676 from Patent EP1572962. BC074936 - Homo sapiens interferon, alpha 2, mRNA (cDNA clone MGC:103885 IMAGE:30915269), complete cds. BC074937 - Homo sapiens interferon, alpha 2, mRNA (cDNA clone MGC:104046 IMAGE:30915492), complete cds. JN591568 - Homo sapiens clone IAS1 interferon alpha 2b (IFNA2B) mRNA, complete cds. JN591569 - Homo sapiens clone IAS2 interferon alpha 2b (IFNA2B) mRNA, complete cds. JN591570 - Homo sapiens clone IAS3 interferon alpha 2b (IFNA2B) mRNA, complete cds. JN848522 - Homo sapiens interferon alpha 2a mRNA, complete cds. KY780371 - Homo sapiens interferon alpha 2b mRNA, complete cds. LQ884075 - Sequence 22 from Patent WO2018160540. AB590747 - Synthetic construct DNA, clone: pFN21AE1670, Homo sapiens IFNA2 gene for interferon, alpha 2, without stop codon, in Flexi system. CR541921 - Homo sapiens full open reading frame cDNA clone RZPDo834E0933D for gene IFNA2, interferon, alpha 2; complete cds, without stopcodon. AY255838 - Homo sapiens interferon alpha 2b mRNA, complete cds. MP518003 - Sequence 22 from Patent WO2020041655.
US Server
