Description: Homo sapiens low density lipoprotein receptor-related protein 10 (LRP10), mRNA. RefSeq Summary (NM_014045): This gene encodes a low density lipoprotein receptor family protein. A similar protein in mouse is thought to play a role in the uptake of apolipoprotein E-containing lipoproteins. [provided by RefSeq, Jul 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Transcript (Including UTRs) Position: hg19 chr14:23,340,960-23,347,291 Size: 6,332 Total Exon Count: 7 Strand: + Coding Region Position: hg19 chr14:23,341,513-23,346,736 Size: 5,224 Coding Exon Count: 7
ID:LRP10_HUMAN DESCRIPTION: RecName: Full=Low-density lipoprotein receptor-related protein 10; Short=LRP-10; Flags: Precursor; FUNCTION: Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver (By similarity). SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential). Membrane, coated pit (By similarity). TISSUE SPECIFICITY: Expressed in blood leukocyte, lung, placenta, small intestine, liver, kidney, spleen, thymus, colon, skeletal muscle and heart. SIMILARITY: Belongs to the LDLR family. SIMILARITY: Contains 2 CUB domains. SIMILARITY: Contains 4 LDL-receptor class A domains. SEQUENCE CAUTION: Sequence=AAD20037.1; Type=Erroneous initiation; Sequence=AAG17980.1; Type=Frameshift; Positions=370, 700; Sequence=AAQ13610.1; Type=Frameshift; Positions=312, 337, 496, 502, 512; Sequence=CAD39174.2; Type=Miscellaneous discrepancy; Note=Chimera;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q7Z4F1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
