Description: Homo sapiens myosin VI (MYO6), mRNA. RefSeq Summary (NM_004999): This gene encodes a reverse-direction motor protein that moves toward the minus end of actin filaments and plays a role in intracellular vesicle and organelle transport. The protein consists of a motor domain containing an ATP- and an actin-binding site and a globular tail which interacts with other proteins. This protein maintains the structural integrity of inner ear hair cells and mutations in this gene cause non-syndromic autosomal dominant and recessive hearing loss. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]. Transcript (Including UTRs) Position: hg19 chr6:76,458,909-76,629,254 Size: 170,346 Total Exon Count: 35 Strand: + Coding Region Position: hg19 chr6:76,527,265-76,624,729 Size: 97,465 Coding Exon Count: 34
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF00063 - Myosin head (motor domain) PF00612 - IQ calmodulin-binding motif PF16521 - Myosin VI cargo binding domain
ModBase Predicted Comparative 3D Structure on Q9UM54-1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BX647397 - Homo sapiens mRNA; cDNA DKFZp686L10144 (from clone DKFZp686L10144). BC012598 - Homo sapiens myosin VI, mRNA (cDNA clone IMAGE:4295486), with apparent retained intron. AB002387 - Homo sapiens mRNA for KIAA0389 gene. BC146764 - Homo sapiens myosin VI, mRNA (cDNA clone MGC:166836 IMAGE:9007206), complete cds. U90236 - Homo sapiens myosin VI (MYO6) mRNA, complete cds. AB385322 - Synthetic construct DNA, clone: pF1KA0389, Homo sapiens MYO6 gene for myosin-VI, complete cds, without stop codon, in Flexi system. KJ891664 - Synthetic construct Homo sapiens clone ccsbBroadEn_01058 MYO6 gene, encodes complete protein. KY781827 - Homo sapiens myosin VI transcript variant 007 (Myo6-007) mRNA, complete cds, alternatively spliced. KY781828 - Homo sapiens myosin VI transcript variant 008 (Myo6-008) mRNA, complete cds, alternatively spliced. L29145 - Homo sapiens myosin mRNA, partial cds. JD368568 - Sequence 349592 from Patent EP1572962. JD126088 - Sequence 107112 from Patent EP1572962. LF208563 - JP 2014500723-A/16066: Polycomb-Associated Non-Coding RNAs. AK095294 - Homo sapiens cDNA FLJ37975 fis, clone CTONG2010133, highly similar to Homo sapiens myosin VI (MYO6) gene. JD292192 - Sequence 273216 from Patent EP1572962. JD244877 - Sequence 225901 from Patent EP1572962. JD502596 - Sequence 483620 from Patent EP1572962. JD504012 - Sequence 485036 from Patent EP1572962. JD376752 - Sequence 357776 from Patent EP1572962. JD537352 - Sequence 518376 from Patent EP1572962. JD194754 - Sequence 175778 from Patent EP1572962. JD185482 - Sequence 166506 from Patent EP1572962. MA444140 - JP 2018138019-A/16066: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9UM54 (Reactome details) participates in the following event(s):
R-HSA-190519 Internalization of gap junction plaques R-HSA-416320 Trafficking of GluR1-containing AMPA receptors R-HSA-190873 Gap junction degradation R-HSA-399719 Trafficking of AMPA receptors R-HSA-190828 Gap junction trafficking R-HSA-399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-157858 Gap junction trafficking and regulation R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission R-HSA-199991 Membrane Trafficking R-HSA-112315 Transmission across Chemical Synapses R-HSA-5653656 Vesicle-mediated transport R-HSA-112316 Neuronal System