Description: Homo sapiens programmed cell death 6 (PDCD6), transcript variant 1, mRNA. RefSeq Summary (NM_013232): This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is also located on the short arm of chromosome 5. [provided by RefSeq, May 2012]. Transcript (Including UTRs) Position: hg19 chr5:271,736-315,089 Size: 43,354 Total Exon Count: 6 Strand: + Coding Region Position: hg19 chr5:271,836-314,630 Size: 42,795 Coding Exon Count: 6
ID:PDCD6_HUMAN DESCRIPTION: RecName: Full=Programmed cell death protein 6; AltName: Full=Apoptosis-linked gene 2 protein; AltName: Full=Probable calcium-binding protein ALG-2; FUNCTION: Calcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. May mediate Ca(2+)- regulated signals along the death pathway (By similarity). Calcium-dependent adapter necessary for the association between PDCD6IP and TSG101. Interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity. SUBUNIT: Self-associates (By similarity). Homodimer. Interacts with PEF1. Interacts with RBM22. Interacts with PLSCR4, ANXA7 and TSG101. Interacts with SEC31A, PDCD6IP, and the N-termini of ANXA11 and PLSCR3 in a calcium-dependent manner. Interacts with DAPK1. INTERACTION: P53355:DAPK1; NbExp=3; IntAct=EBI-352915, EBI-358616; Q8WUM4:PDCD6IP; NbExp=5; IntAct=EBI-352915, EBI-310624; Q9NRY6:PLSCR3; NbExp=9; IntAct=EBI-352915, EBI-750734; O94979:SEC31A; NbExp=6; IntAct=EBI-352915, EBI-1767898; SUBCELLULAR LOCATION: Nucleus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Nucleus. Note=Interaction with RBM22 induces relocalization from the cytoplasm to the nucleus. Translocated from the cytoplasm to the nucleus after heat shock cell treatment. Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules. SIMILARITY: Contains 5 EF-hand domains. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/PDCD6ID43402ch5p15.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O75340
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001525 angiogenesis GO:0001938 positive regulation of endothelial cell proliferation GO:0006508 proteolysis GO:0006886 intracellular protein transport GO:0006888 ER to Golgi vesicle-mediated transport GO:0006915 apoptotic process GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0010595 positive regulation of endothelial cell migration GO:0014029 neural crest formation GO:0014032 neural crest cell development GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway GO:0032007 negative regulation of TOR signaling GO:0034605 cellular response to heat GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0045766 positive regulation of angiogenesis GO:0048208 COPII vesicle coating GO:0051592 response to calcium ion GO:0051898 negative regulation of protein kinase B signaling GO:0097190 apoptotic signaling pathway GO:1902527 positive regulation of protein monoubiquitination