Human Gene PIK3R1 (uc003jva.3)
  Description: Homo sapiens phosphoinositide-3-kinase, regulatory subunit 1 (alpha) (PIK3R1), transcript variant 1, mRNA.
RefSeq Summary (NM_181523): Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011].
Transcript (Including UTRs)
   Position: hg19 chr5:67,511,584-67,597,649 Size: 86,066 Total Exon Count: 16 Strand: +
Coding Region
   Position: hg19 chr5:67,522,504-67,593,429 Size: 70,926 Coding Exon Count: 15 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsMalaCards
CTDGene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesGeneReviews
Model InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:67,511,584-67,597,649)mRNA (may differ from genome)Protein (724 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMalacards
MGIneXtProtOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: P85A_HUMAN
DESCRIPTION: RecName: Full=Phosphatidylinositol 3-kinase regulatory subunit alpha; Short=PI3-kinase regulatory subunit alpha; Short=PI3K regulatory subunit alpha; Short=PtdIns-3-kinase regulatory subunit alpha; AltName: Full=Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; Short=PI3-kinase subunit p85-alpha; Short=PtdIns-3-kinase regulatory subunit p85-alpha;
FUNCTION: Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling.
SUBUNIT: Heterodimer of a regulatory subunit PIK3R1 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD). Interacts with FER. Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated). Interacts with PTK2/FAK1 (By similarity). Interacts with phosphorylated TOM1L1. Interacts with phosphorylated LIME1 upon TCR and/or BCR activation. Interacts with SOCS7. Interacts with RUFY3. Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated). Interacts with LYN (via SH3 domain); this enhances enzyme activity (By similarity). Interacts with phosphorylated LAT, LAX1 and TRAT1 upon TCR activation. Interacts with CBLB. Interacts with HIV-1 Nef to activate the Nef associated p21-activated kinase (PAK). This interaction depends on the C-terminus of both proteins and leads to increased production of HIV. Interacts with HCV NS5A. The SH2 domains interact with the YTHM motif of phosphorylated INSR in vitro. Also interacts with tyrosine-phosphorylated IGF1R in vitro. Interacts with CD28 and CD3Z upon T-cell activation. Interacts with IRS1 and phosphorylated IRS4, as well as with NISCH and HCST. Interacts with FASLG, KIT and BCR. Interacts with AXL, FGFR1, FGFR2, FGFR3 and FGFR4 (phosphorylated). Interacts with FGR and HCK. Interacts with PDGFRA (tyrosine phosphorylated) and PDGFRB (tyrosine phosphorylated). Interacts with ERBB4 (phosphorylated). Interacts with NTRK1 (phosphorylated upon ligand-binding).
INTERACTION: P42684:ABL2; NbExp=2; IntAct=EBI-79464, EBI-1102694; Q8WX92:COBRA1; NbExp=2; IntAct=EBI-79464, EBI-347721; Q9Y2H0:DLGAP4; NbExp=2; IntAct=EBI-79464, EBI-722139; P21860:ERBB3; NbExp=23; IntAct=EBI-79464, EBI-720706; P62993:GRB2; NbExp=3; IntAct=EBI-79464, EBI-401755; Q86VI4-3:LAPTM4B; NbExp=2; IntAct=EBI-79464, EBI-3267286; Q92918:MAP4K1; NbExp=2; IntAct=EBI-79464, EBI-881; P42336:PIK3CA; NbExp=2; IntAct=EBI-79464, EBI-2116585; Q13905:RAPGEF1; NbExp=2; IntAct=EBI-79464, EBI-976876; P26373:RPL13; NbExp=2; IntAct=EBI-79464, EBI-356849; P19793:RXRA; NbExp=8; IntAct=EBI-79464, EBI-78598; Q9UPX8:SHANK2; NbExp=2; IntAct=EBI-79464, EBI-1570571; Q96EB6:SIRT1; NbExp=3; IntAct=EBI-79464, EBI-1802965; Q07889:SOS1; NbExp=2; IntAct=EBI-79464, EBI-297487; Q15661:TPSAB1; NbExp=2; IntAct=EBI-79464, EBI-1761369; Q9ULW0:TPX2; NbExp=2; IntAct=EBI-79464, EBI-1037322;
TISSUE SPECIFICITY: Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level).
DOMAIN: The SH3 domain mediates the binding to CBLB, and to HIV-1 Nef.
PTM: Polyubiquitinated in T-cells by CBLB; which does not promote proteasomal degradation but impairs association with CD28 and CD3Z upon T-cell activation.
PTM: Phosphorylated. Tyrosine phosphorylated in response to signaling by FGFR1, FGFR2, FGFR3 and FGFR4. Phosphorylated by CSF1R. Phosphorylated by ERBB4. Phosphorylated on tyrosine residues by TEK/TIE2. Dephosphorylated by PTPRJ. Phosphorylated by PIK3CA at Ser-608; phosphorylation is stimulated by insulin and PDGF. The relevance of phosphorylation by PIK3CA is however unclear (By similarity). Phosphorylated in response to KIT and KITLG/SCF. Phosphorylated by FGR.
SIMILARITY: Belongs to the PI3K p85 subunit family.
SIMILARITY: Contains 1 Rho-GAP domain.
SIMILARITY: Contains 2 SH2 domains.
SIMILARITY: Contains 1 SH3 domain.

-  Primer design for this transcript
 

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Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): PIK3R1
CDC HuGE Published Literature: PIK3R1
Positive Disease Associations: Arteries , Body Mass Index , Body Weight , Cholesterol , periodontitis , Tunica Media
Related Studies:
  1. Arteries
    , , . [PubMed 0]
  2. Body Mass Index
    , , . [PubMed 0]
  3. Body Weight
    Caroline S Fox et al. BMC medical genetics 2007, Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project., BMC medical genetics. [PubMed 17903300]
    Adiposity traits are associated with SNPs on the Affymetrix 100K SNP GeneChip. Replication of these initial findings is necessary. These data will serve as a resource for replication as more genes become identified with BMI and WC.
           more ... click here to view the complete list

-  MalaCards Disease Associations
  MalaCards Gene Search: PIK3R1
Diseases sorted by gene-association score: short syndrome* (1587), agammaglobulinemia 7, autosomal recessive* (1069), immunodeficiency 36* (1018), agammaglobulinemia, non-bruton type* (247), pasli disease* (202), agammaglobulinemia (10), hypersplenism (7), acute insulin response (6), erythrocytosis, somatic (5), leopard syndrome (5), glioblastoma multiforme (4), breast cancer (4), endometrial cancer (3), hiv-1 (3), lung cancer (2), colorectal cancer (2), insulin-like growth factor i (2), prostate cancer (2), diabetes mellitus, noninsulin-dependent (2)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 54.85 RPKM in Nerve - Tibial
Total median expression: 901.76 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -229.52580-0.396 Picture PostScript Text
3' UTR -1221.424220-0.289 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001720 - PI3kinase_P85
IPR008936 - Rho_GTPase_activation_prot
IPR000198 - RhoGAP_dom
IPR000980 - SH2
IPR011511 - SH3_2
IPR001452 - SH3_domain

Pfam Domains:
PF00017 - SH2 domain
PF00620 - RhoGAP domain
PF16454 - Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain

SCOP Domains:
48350 - GTPase activation domain, GAP
50044 - SH3-domain
55550 - SH2 domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1A0N - NMR MuPIT 1AZG - NMR MuPIT 1H9O - X-ray MuPIT 1PBW - X-ray MuPIT 1PHT - X-ray MuPIT 1PIC - NMR MuPIT 1PKS - NMR MuPIT 1PKT - NMR MuPIT 2IUG - X-ray MuPIT 2IUH - X-ray MuPIT 2IUI - X-ray MuPIT 2RD0 - X-ray MuPIT 2V1Y - X-ray MuPIT 3HHM - X-ray MuPIT 3HIZ - X-ray MuPIT 3I5R - X-ray MuPIT 3I5S - X-ray MuPIT 4A55 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P27986
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
 Gene Details    
 Gene Sorter    
 RGDEnsembl   
 Protein SequenceProtein Sequence   
 AlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001784 phosphotyrosine binding
GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005158 insulin receptor binding
GO:0005159 insulin-like growth factor receptor binding
GO:0005168 neurotrophin TRKA receptor binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0019903 protein phosphatase binding
GO:0035014 phosphatidylinositol 3-kinase regulator activity
GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding
GO:0043125 ErbB-3 class receptor binding
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0043559 insulin binding
GO:0043560 insulin receptor substrate binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046935 1-phosphatidylinositol-3-kinase regulator activity
GO:0046982 protein heterodimerization activity

Biological Process:
GO:0001678 cellular glucose homeostasis
GO:0001953 negative regulation of cell-matrix adhesion
GO:0006468 protein phosphorylation
GO:0006606 protein import into nucleus
GO:0007162 negative regulation of cell adhesion
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007411 axon guidance
GO:0008286 insulin receptor signaling pathway
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0015031 protein transport
GO:0016032 viral process
GO:0019221 cytokine-mediated signaling pathway
GO:0030168 platelet activation
GO:0030183 B cell differentiation
GO:0030335 positive regulation of cell migration
GO:0031295 T cell costimulation
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032869 cellular response to insulin stimulus
GO:0033120 positive regulation of RNA splicing
GO:0034644 cellular response to UV
GO:0034976 response to endoplasmic reticulum stress
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0038128 ERBB2 signaling pathway
GO:0042307 positive regulation of protein import into nucleus
GO:0043066 negative regulation of apoptotic process
GO:0043551 regulation of phosphatidylinositol 3-kinase activity
GO:0045671 negative regulation of osteoclast differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046326 positive regulation of glucose import
GO:0046626 regulation of insulin receptor signaling pathway
GO:0046854 phosphatidylinositol phosphorylation
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0050821 protein stabilization
GO:0050852 T cell receptor signaling pathway
GO:0050900 leukocyte migration
GO:0051492 regulation of stress fiber assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0060396 growth hormone receptor signaling pathway
GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response
GO:1903076 regulation of protein localization to plasma membrane
GO:1903078 positive regulation of protein localization to plasma membrane
GO:2001275 positive regulation of glucose import in response to insulin stimulus

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005801 cis-Golgi network
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005942 phosphatidylinositol 3-kinase complex
GO:0005943 phosphatidylinositol 3-kinase complex, class IA
GO:0016020 membrane
GO:0032991 macromolecular complex
GO:1990578 perinuclear endoplasmic reticulum membrane


-  Descriptions from all associated GenBank mRNAs
  BC094795 - Homo sapiens phosphoinositide-3-kinase, regulatory subunit 1 (alpha), mRNA (cDNA clone MGC:104749 IMAGE:30528412), complete cds.
KU214570 - Homo sapiens PIK3R1/NR4A3 fusion protein (PIK3R1/NR4A3 fusion) mRNA, partial cds.
M61906 - Human P13-kinase associated p85 mRNA sequence.
JD066905 - Sequence 47929 from Patent EP1572962.
AK299743 - Homo sapiens cDNA FLJ61371 complete cds, highly similar to Phosphatidylinositol 3-kinase regulatory subunit alpha.
KU170088 - Homo sapiens NR4A3/PIK3R1 fusion protein (NR4A3/PIK3R1 fusion) mRNA, partial cds.
AF279367 - Homo sapiens phosphoinositide 3-kinase p85 subunit splicing variant p46 mRNA, complete cds, alternatively spliced.
AK000121 - Homo sapiens cDNA FLJ20114 fis, clone COL05477, highly similar to P85A_HUMAN PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY ALPHA SUBUNIT.
AK223613 - Homo sapiens mRNA for phosphoinositide-3-kinase, regulatory subunit, polypeptide 1 isoform 2 variant, clone: FCC133D09.
BC030815 - Homo sapiens phosphoinositide-3-kinase, regulatory subunit 1 (alpha), mRNA (cDNA clone MGC:22760 IMAGE:4290954), complete cds.
CU689026 - Synthetic construct Homo sapiens gateway clone IMAGE:100022306 5' read PIK3R1 mRNA.
HQ447692 - Synthetic construct Homo sapiens clone IMAGE:100071020; CCSB012865_03 phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) (PIK3R1) gene, encodes complete protein.
KJ897334 - Synthetic construct Homo sapiens clone ccsbBroadEn_06728 PIK3R1 gene, encodes complete protein.
KJ905267 - Synthetic construct Homo sapiens clone ccsbBroadEn_14763 PIK3R1 gene, encodes complete protein.
KR711186 - Synthetic construct Homo sapiens clone CCSBHm_00021011 PIK3R1 (PIK3R1) mRNA, encodes complete protein.
KR711187 - Synthetic construct Homo sapiens clone CCSBHm_00021012 PIK3R1 (PIK3R1) mRNA, encodes complete protein.
AK126345 - Homo sapiens cDNA FLJ44373 fis, clone TRACH3009455, highly similar to Phosphatidylinositol 3-kinase regulatory subunit alpha.
JX133164 - Homo sapiens isolate G001 phosphoinositide-3-kinase regulatory subunit (PIK3R1) mRNA, partial cds.
JX133165 - Homo sapiens isolate G002 phosphoinositide-3-kinase regulatory subunit (PIK3R1) mRNA, partial cds.
AK094785 - Homo sapiens cDNA FLJ37466 fis, clone BRAWH2011860, highly similar to Phosphatidylinositol 3-kinase regulatory subunit alpha.
AK294919 - Homo sapiens cDNA FLJ55204 complete cds, highly similar to Phosphatidylinositol 3-kinase regulatory subunit alpha.
JD534296 - Sequence 515320 from Patent EP1572962.
JD338438 - Sequence 319462 from Patent EP1572962.
JD154720 - Sequence 135744 from Patent EP1572962.
JD157901 - Sequence 138925 from Patent EP1572962.
JD442348 - Sequence 423372 from Patent EP1572962.
JD065183 - Sequence 46207 from Patent EP1572962.
JD565836 - Sequence 546860 from Patent EP1572962.
JD382162 - Sequence 363186 from Patent EP1572962.
JD565930 - Sequence 546954 from Patent EP1572962.
JD280622 - Sequence 261646 from Patent EP1572962.
JD044703 - Sequence 25727 from Patent EP1572962.
JD226614 - Sequence 207638 from Patent EP1572962.
JD483457 - Sequence 464481 from Patent EP1572962.
JD193713 - Sequence 174737 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04012 - ErbB signaling pathway
hsa04062 - Chemokine signaling pathway
hsa04070 - Phosphatidylinositol signaling system
hsa04150 - mTOR signaling pathway
hsa04210 - Apoptosis
hsa04370 - VEGF signaling pathway
hsa04510 - Focal adhesion
hsa04620 - Toll-like receptor signaling pathway
hsa04630 - Jak-STAT signaling pathway
hsa04650 - Natural killer cell mediated cytotoxicity
hsa04660 - T cell receptor signaling pathway
hsa04662 - B cell receptor signaling pathway
hsa04664 - Fc epsilon RI signaling pathway
hsa04666 - Fc gamma R-mediated phagocytosis
hsa04670 - Leukocyte transendothelial migration
hsa04722 - Neurotrophin signaling pathway
hsa04810 - Regulation of actin cytoskeleton
hsa04910 - Insulin signaling pathway
hsa04914 - Progesterone-mediated oocyte maturation
hsa04930 - Type II diabetes mellitus
hsa04960 - Aldosterone-regulated sodium reabsorption
hsa05100 - Bacterial invasion of epithelial cells
hsa05142 - Chagas disease
hsa05200 - Pathways in cancer
hsa05210 - Colorectal cancer
hsa05211 - Renal cell carcinoma
hsa05212 - Pancreatic cancer
hsa05213 - Endometrial cancer
hsa05214 - Glioma
hsa05215 - Prostate cancer
hsa05218 - Melanoma
hsa05220 - Chronic myeloid leukemia
hsa05221 - Acute myeloid leukemia
hsa05222 - Small cell lung cancer
hsa05223 - Non-small cell lung cancer

BioCyc Knowledge Library
PWY-6352 - 3-phosphoinositide biosynthesis
PWY3DJ-219 - PIP metabolism

BioCarta from NCI Cancer Genome Anatomy Project
h_ctla4Pathway - The Co-Stimulatory Signal During T-cell Activation
h_arfPathway - Tumor Suppressor Arf Inhibits Ribosomal Biogenesis
h_hcmvPathway - Human Cytomegalovirus and Map Kinase Pathways
h_longevityPathway - The IGF-1 Receptor and Longevity
h_pdgfPathway - PDGF Signaling Pathway
h_Par1Pathway - Thrombin signaling and protease-activated receptors
h_mTORPathway - mTOR Signaling Pathway
h_TPOPathway - TPO Signaling Pathway
h_erk5Pathway - Role of Erk5 in Neuronal Survival
h_gcrPathway - Corticosteroids and cardioprotection
h_crebPathway - Transcription factor CREB and its extracellular signals
h_igf1mtorpathway - Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway
h_ecmPathway - Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia
h_il2rbPathway - IL-2 Receptor Beta Chain in T cell Activation
h_metPathway - Signaling of Hepatocyte Growth Factor Receptor
h_rac1Pathway - Rac 1 cell motility signaling pathway
h_aktPathway - AKT Signaling Pathway
h_cdc42racPathway - Role of PI3K subunit p85 in regulation of Actin Organization and Cell Migration
h_egfPathway - EGF Signaling Pathway
h_bcellsurvivalPathway - B Cell Survival Pathway
h_hdacPathway - Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK)
h_her2Pathway - Role of ERBB2 in Signal Transduction and Oncology
h_insulinPathway - Insulin Signaling Pathway
h_tcrPathway - T Cell Receptor Signaling Pathway
h_vegfPathway - VEGF, Hypoxia, and Angiogenesis
h_cxcr4Pathway - CXCR4 Signaling Pathway
h_achPathway - Role of nicotinic acetylcholine receptors in the regulation of apoptosis
h_badPathway - Regulation of BAD phosphorylation
h_edg1Pathway - Phospholipids as signalling intermediaries
h_igf1Pathway - IGF-1 Signaling Pathway
h_il7Pathway - IL-7 Signal Transduction
h_ngfPathway - Nerve growth factor pathway (NGF)
h_plcPathway - Phospholipase C Signaling Pathway
h_nkcellsPathway - Ras-Independent pathway in NK cell-mediated cytotoxicity
h_ghPathway - Growth Hormone Signaling Pathway
h_gleevecpathway - Inhibition of Cellular Proliferation by Gleevec
h_nfatPathway - NFAT and Hypertrophy of the heart (Transcription in the broken heart)
h_pparaPathway - Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)
h_gsk3Pathway - Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages
h_ptenPathway - PTEN dependent cell cycle arrest and apoptosis
h_ctcfPathway - CTCF: First Multivalent Nuclear Factor
h_rasPathway - Ras Signaling Pathway
h_tffPathway - Trefoil Factors Initiate Mucosal Healing
h_RacCycDPathway - Influence of Ras and Rho proteins on G1 to S Transition
h_eif4Pathway - Regulation of eIF4e and p70 S6 Kinase
h_igf1rPathway - Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation
h_trkaPathway - Trka Receptor Signaling Pathway
h_fcer1Pathway - Fc Epsilon Receptor I Signaling in Mast Cells

Reactome (by CSHL, EBI, and GO)

Protein P27986 (Reactome details) participates in the following event(s):

R-HSA-177931 Binding of PIK3 regulatory alpha subunit to GRB2:GAB1
R-HSA-443402 GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K
R-HSA-1839114 BCR-FGFR1:GRB2:p-GAB2 binds PIK3R1
R-HSA-1250353 Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
R-HSA-1226016 Binding of GRB2:GAB1:PIK3R1 complex to ligand-responsive p-6Y-EGFR mutants
R-HSA-5637764 Binding of GRB2:GAB1:PIK3R1 complex to p-EGFRvIII mutant
R-HSA-5654592 Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1
R-HSA-5654594 Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
R-HSA-5654612 Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1
R-HSA-5654620 Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
R-HSA-5654637 Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1
R-HSA-5654641 Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
R-HSA-5654659 Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1
R-HSA-5654667 Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
R-HSA-5655240 Activated FGFR1 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
R-HSA-5655248 Activated FGFR4 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
R-HSA-5655315 Activated FGFR3 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
R-HSA-5655320 Activated FGFR2 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
R-HSA-8853316 Activated FGFR3 fusions:p-FRS2 binds GRB2:GAB1:PIK3R1
R-HSA-177927 PI3K binds to EGF:EGFR:GRB2:GAB1
R-HSA-1250189 Binding of PI3K to ERBB2:P-ERBB3 heterodimer
R-HSA-1250346 Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
R-HSA-1306965 Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
R-HSA-8851954 Phosphorylated GAB1 recruits PI3K to MET
R-HSA-1839102 BCR-FGFR1 fusion:GRB2:p-GAB2:PIK3R1 binds PIK3CA
R-HSA-1839080 Activated cytosolic FGFR1 fusions bind PIK3CA
R-HSA-1295516 IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 binds PI3K regulatory subunits
R-HSA-1250372 Recruitment of PI3K subunit p110 (PIK3CA) to PI3K subunit p85 (PIK3R1) bound to p-ERBB4cyt1 homodimers
R-HSA-1226012 Binding of PI3K p110 subunit alpha (PIK3CA) to complex of GRB2:GAB1:PIK3R1 and ligand-responsive p-6Y-EGFR mutants
R-HSA-5637765 Binding of PI3K p110 subunit alpha (PIK3CA) to complex of GRB2:GAB1:PIK3R1 and p-EGFRvIII
R-HSA-5654596 Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
R-HSA-5654591 Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
R-HSA-5654614 Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
R-HSA-5654662 Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
R-HSA-5654622 Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
R-HSA-5654643 Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
R-HSA-5654640 Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
R-HSA-5654669 Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
R-HSA-5655263 Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
R-HSA-5655285 Activated FGFR3 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
R-HSA-5655245 Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
R-HSA-5655252 Activated FGFR4 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
R-HSA-8853308 Activated FGFR3 fusions:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
R-HSA-74737 p-Y-IRS1,p-Y-IRS2 bind PI3K
R-HSA-186780 PI3-kinase binds to the active receptor
R-HSA-198315 Active IRS recruits PI3K to the plasma membrane and activates it
R-HSA-202203 Recruitment of PI3K to plasma membrane
R-HSA-204798 Interaction of Tie2 and p85 of PI3K
R-HSA-451758 p85 associates with both p-Nephrin and CD2AP
R-HSA-2029273 PI3K binds to p-6Y-SYK
R-HSA-2424482 p85 regulatory unit of PI3K binds p-6Y-SYK
R-HSA-2730842 PI3K associates with phosphorylated GAB2
R-HSA-5218852 p-6Y-VEGFR2 binds PI3K
R-HSA-5357479 p-AXL binds PI3K
R-HSA-114542 Rac1 activation of PI3K
R-HSA-205262 Direct recruitment of PI3K to p-KIT
R-HSA-388830 PI3K binds ICOS
R-HSA-388832 PI3K binds CD28
R-HSA-416358 G alpha (q) inhibits PI3K alpha
R-HSA-1562641 Indirect recruitment of PI3K to KIT via p(Y)-GAB2
R-HSA-1676109 PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
R-HSA-1676048 PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
R-HSA-177939 PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
R-HSA-1306979 PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
R-HSA-8852019 MET bound PI3K generates PIP3
R-HSA-1839107 BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3.
R-HSA-1839091 Cytosolic FGFR1 fusion protein-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-508247 Gab2 binds the p85 subunit of Class 1A PI3 kinases
R-HSA-879917 CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
R-HSA-914182 14-3-3 zeta binding allows recruitment of PI3K
R-HSA-2045911 BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3
R-HSA-2076220 CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3
R-HSA-1250462 PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
R-HSA-1250370 Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
R-HSA-1306957 PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
R-HSA-2400009 PI3K inhibitors block PI3K catalytic activity
R-HSA-2394007 PI3K gain of function mutants phosphorylate PIP2 to PIP3
R-HSA-1226014 Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants
R-HSA-5637801 Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII
R-HSA-5654692 FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5654690 FGFR1-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5654701 FGFR2-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5654717 FGFR4-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5654697 FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5654709 FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5654705 FGFR3-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5654714 FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5655290 Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5655289 Activated FGFR3 mutant-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5655323 Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5655235 Activated FGFR4 mutant-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-8853323 Activated FGFR3 fusion-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-2316434 PI3K phosphorylates PIP2 to PIP3
R-HSA-186800 PI3K catalyses the phosphorylation of PIP2 to PIP3
R-HSA-198266 PI3K produces PIP3 and other phosphatidyl inositides
R-HSA-202365 PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
R-HSA-2029271 PI3K phosphorylates PIP2 to PIP3
R-HSA-2424480 PI3K phosphorylates PIP2 to PIP3
R-HSA-2730870 Phosphorylation of PIP2 to PIP3 by PI3K
R-HSA-389158 CD28 bound PI3K phosphorylates PIP2 to PIP3
R-HSA-437162 PI3K alpha, beta, gamma convert PIP2 to PIP3
R-HSA-912629 CBL is tyrosine phosphorylated
R-HSA-109699 PI3K-containing complexes phosphorylate PIP2 to PIP3
R-HSA-5218819 VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
R-HSA-1433514 Synthesis of PIP3 from PIP2 by PI3K
R-HSA-5654689 PI-3K cascade:FGFR1
R-HSA-5654695 PI-3K cascade:FGFR2
R-HSA-5654710 PI-3K cascade:FGFR3
R-HSA-5654720 PI-3K cascade:FGFR4
R-HSA-430116 GP1b-IX-V activation signalling
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants
R-HSA-1250342 PI3K events in ERBB4 signaling
R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
R-HSA-5637810 Constitutive Signaling by EGFRvIII
R-HSA-5655302 Signaling by FGFR1 in disease
R-HSA-5655291 Signaling by FGFR4 in disease
R-HSA-8853338 Signaling by FGFR3 point mutants in cancer
R-HSA-5655253 Signaling by FGFR2 in disease
R-HSA-8853334 Signaling by FGFR3 fusions in cancer
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
R-HSA-180292 GAB1 signalosome
R-HSA-1963642 PI3K events in ERBB2 signaling
R-HSA-8851907 MET activates PI3K/AKT signaling
R-HSA-9028335 Activated NTRK2 signals through PI3K
R-HSA-6785807 Interleukin-4 and 13 signaling
R-HSA-1266695 Interleukin-7 signaling
R-HSA-5654687 Downstream signaling of activated FGFR1
R-HSA-5654696 Downstream signaling of activated FGFR2
R-HSA-5654708 Downstream signaling of activated FGFR3
R-HSA-5654716 Downstream signaling of activated FGFR4
R-HSA-76002 Platelet activation, signaling and aggregation
R-HSA-1839124 FGFR1 mutant receptor activation
R-HSA-1236394 Signaling by ERBB4
R-HSA-5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer
R-HSA-5637812 Signaling by EGFRvIII in Cancer
R-HSA-1226099 Signaling by FGFR in disease
R-HSA-5655332 Signaling by FGFR3 in disease
R-HSA-983705 Signaling by the B Cell Receptor (BCR)
R-HSA-177929 Signaling by EGFR
R-HSA-1227986 Signaling by ERBB2
R-HSA-6806834 Signaling by MET
R-HSA-9006115 Signaling by NTRK2 (TRKB)
R-HSA-109704 PI3K Cascade
R-HSA-186763 Downstream signal transduction
R-HSA-198203 PI3K/AKT activation
R-HSA-202424 Downstream TCR signaling
R-HSA-210993 Tie2 Signaling
R-HSA-373753 Nephrin family interactions
R-HSA-2029485 Role of phospholipids in phagocytosis
R-HSA-2424491 DAP12 signaling
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-416482 G alpha (12/13) signalling events
R-HSA-1433557 Signaling by SCF-KIT
R-HSA-388841 Costimulation by the CD28 family
R-HSA-389357 CD28 dependent PI3K/Akt signaling
R-HSA-416476 G alpha (q) signalling events
R-HSA-114604 GPVI-mediated activation cascade
R-HSA-449147 Signaling by Interleukins
R-HSA-5654736 Signaling by FGFR1
R-HSA-5654738 Signaling by FGFR2
R-HSA-5654741 Signaling by FGFR3
R-HSA-5654743 Signaling by FGFR4
R-HSA-109582 Hemostasis
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-1643713 Signaling by EGFR in Cancer
R-HSA-5663202 Diseases of signal transduction
R-HSA-1660499 Synthesis of PIPs at the plasma membrane
R-HSA-1280218 Adaptive Immune System
R-HSA-166520 Signaling by NTRKs
R-HSA-112399 IRS-mediated signalling
R-HSA-186797 Signaling by PDGF
R-HSA-187037 Signaling by NTRK1 (TRKA)
R-HSA-202403 TCR signaling
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-1500931 Cell-Cell communication
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis
R-HSA-2172127 DAP12 interactions
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-194138 Signaling by VEGF
R-HSA-912526 Interleukin receptor SHC signaling
R-HSA-912631 Regulation of signaling by CBL
R-HSA-512988 Interleukin-3, 5 and GM-CSF signaling
R-HSA-8853659 RET signaling
R-HSA-388396 GPCR downstream signalling
R-HSA-389356 CD28 co-stimulation
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-190236 Signaling by FGFR
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-1483255 PI Metabolism
R-HSA-168256 Immune System
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-74751 Insulin receptor signalling cascade
R-HSA-2428928 IRS-related events triggered by IGF1R
R-HSA-168249 Innate Immune System
R-HSA-451927 Interleukin-2 family signaling
R-HSA-422475 Axon guidance
R-HSA-372790 Signaling by GPCR
R-HSA-2219528 PI3K/AKT Signaling in Cancer
R-HSA-1483257 Phospholipid metabolism
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-199418 Negative regulation of the PI3K/AKT network
R-HSA-74752 Signaling by Insulin receptor
R-HSA-2428924 IGF1R signaling cascade
R-HSA-1266738 Developmental Biology
R-HSA-556833 Metabolism of lipids
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: D3DWA0, GRB1, NM_181523, NP_852664, P27986, P85A_HUMAN, Q15747, Q4VBZ7, Q53EM6, Q8IXA2, Q8N1C5
UCSC ID: uc003jva.3
RefSeq Accession: NM_181523
Protein: P27986 (aka P85A_HUMAN)
CCDS: CCDS3993.1

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene PIK3R1:
short (SHORT Syndrome)

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_181523.2
exon count: 16CDS single in 3' UTR: no RNA size: 6991
ORF size: 2175CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4311.00frame shift in genome: no % Coverage: 99.77
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.