Description: Homo sapiens phospholipase C, beta 3 (phosphatidylinositol-specific) (PLCB3), transcript variant 1, mRNA. RefSeq Summary (NM_000932): This gene encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]. Transcript (Including UTRs) Position: hg19 chr11:64,018,995-64,036,924 Size: 17,930 Total Exon Count: 31 Strand: + Coding Region Position: hg19 chr11:64,019,122-64,035,028 Size: 15,907 Coding Exon Count: 31
Attention Deficit Disorder with Hyperactivity Eric Mick et al. Journal of the American Academy of Child and Adolescent Psychiatry 2011, Genome-wide association study of the child behavior checklist dysregulation profile., Journal of the American Academy of Child and Adolescent Psychiatry.
[PubMed 21784300]
We found suggestive evidence for developmentally expressed genes operant in hippocampal dependent memory and learning with the CBCL-DP.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q01970
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.