Description: Homo sapiens protein kinase, AMP-activated, alpha 1 catalytic subunit (PRKAA1), transcript variant 2, mRNA. RefSeq Summary (NM_206907): The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr5:40,759,481-40,798,297 Size: 38,817 Total Exon Count: 10 Strand: - Coding Region Position: hg19 chr5:40,762,880-40,798,291 Size: 35,412 Coding Exon Count: 10
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Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): PRKAA1 CDC HuGE Published Literature: PRKAA1 Positive Disease Associations: Stomach Neoplasms Related Studies:
Stomach Neoplasms Yongyong Shi et al. Nature genetics 2011, A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1., Nature genetics.
[PubMed 22037551]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF00069 - Protein kinase domain PF07714 - Protein tyrosine kinase PF16579 - Adenylate sensor of SNF1-like protein kinase
SCOP Domains: 56112 - Protein kinase-like (PK-like)
ModBase Predicted Comparative 3D Structure on Q13131-2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BioCarta from NCI Cancer Genome Anatomy Project h_chrebpPathway - ChREBP regulation by carbohydrates and cAMP h_leptinPathway - Reversal of Insulin Resistance by Leptin
Reactome (by CSHL, EBI, and GO)
Protein Q13131 (Reactome details) participates in the following event(s):
US Server
