Description: Homo sapiens Ras homolog enriched in brain (RHEB), mRNA. RefSeq Summary (NM_005614): This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr7:151,163,098-151,217,010 Size: 53,913 Total Exon Count: 8 Strand: - Coding Region Position: hg19 chr7:151,164,205-151,216,597 Size: 52,393 Coding Exon Count: 8
ID:RHEB_HUMAN DESCRIPTION: RecName: Full=GTP-binding protein Rheb; AltName: Full=Ras homolog enriched in brain; Flags: Precursor; FUNCTION: Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Activates the protein kinase activity of mTORC1. Has low intrinsic GTPase activity. ENZYME REGULATION: Alternates between an inactive form bound to GDP and an active form bound to GTP. Inactivated by TSC1-TSC2 via the GTPase activating protein (GAP) domain of TSC2. SUBUNIT: Binds to mTORC1 in a guanyl nucleotide-independent manner. Interacts directly with MTOR, MLST8 and RPTOR. Interacts with TSC2. SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). TISSUE SPECIFICITY: Ubiquitous. Highest levels observed in skeletal and cardiac muscle. PTM: Farnesylation is important for efficiently activating mTORC1- mediated signaling. PTM: Phosphorylation by MAPKAPK5 impairs GTP-binding and inactivation (By similarity). MISCELLANEOUS: The conserved catalytic Gln-64 found in other Ras- like GTPases seems not to be involved in GTP hydrolysis in RHEB. SIMILARITY: Belongs to the small GTPase superfamily. Rheb family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q15382
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0007050 cell cycle arrest GO:0007165 signal transduction GO:0016241 regulation of macroautophagy GO:0032006 regulation of TOR signaling GO:0032008 positive regulation of TOR signaling GO:0048714 positive regulation of oligodendrocyte differentiation GO:2000074 regulation of type B pancreatic cell development
US Server
