Description: Homo sapiens threonyl-tRNA synthetase (TARS1), transcript variant 1, mRNA. RefSeq Summary (NM_152295): Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Threonyl-tRNA synthetase belongs to the class-II aminoacyl-tRNA synthetase family [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr5:33,440,882-33,468,196 Size: 27,315 Total Exon Count: 19 Strand: + Coding Region Position: hg19 chr5:33,441,193-33,467,813 Size: 26,621 Coding Exon Count: 19
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00587 - tRNA synthetase class II core domain (G, H, P, S and T) PF02824 - TGS domain PF03129 - Anticodon binding domain PF07973 - Threonyl and Alanyl tRNA synthetase second additional domain
SCOP Domains: 52954 - Anticodon-binding domain of Class II aaRS 55681 - Class II aaRS and biotin synthetases 81271 - TGS-like 55186 - ThrRS/AlaRS common domain
ModBase Predicted Comparative 3D Structure on P26639
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
