Description: Homo sapiens ubiquitin-conjugating enzyme E2D 2 (UBE2D2), transcript variant 1, mRNA. RefSeq Summary (NM_003339): Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]. Transcript (Including UTRs) Position: hg19 chr5:138,940,751-139,008,018 Size: 67,268 Total Exon Count: 7 Strand: + Coding Region Position: hg19 chr5:138,941,377-139,006,386 Size: 65,010 Coding Exon Count: 7
ID:UB2D2_HUMAN DESCRIPTION: RecName: Full=Ubiquitin-conjugating enzyme E2 D2; EC=6.3.2.19; AltName: Full=Ubiquitin carrier protein D2; AltName: Full=Ubiquitin-conjugating enzyme E2(17)KB 2; AltName: Full=Ubiquitin-conjugating enzyme E2-17 kDa 2; AltName: Full=Ubiquitin-protein ligase D2; FUNCTION: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP- induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3. CATALYTIC ACTIVITY: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex and with E3 ubiquitin-protein ligase PJA2 (By similarity). Interacts with PDZRN3 (By similarity). Interacts with CNOT4 (via RING domain). INTERACTION: O15151:MDM4; NbExp=2; IntAct=EBI-347677, EBI-398437; Q96FW1:OTUB1; NbExp=2; IntAct=EBI-347677, EBI-1058491; Q9Y3C5:RNF11; NbExp=4; IntAct=EBI-347677, EBI-396669; Q68DV7:RNF43; NbExp=2; IntAct=EBI-347677, EBI-1647060; Q99942:RNF5; NbExp=3; IntAct=EBI-347677, EBI-348482; Q9Y4K3:TRAF6; NbExp=2; IntAct=EBI-347677, EBI-359276; P98170:XIAP; NbExp=2; IntAct=EBI-347677, EBI-517127; Q8ND25:ZNRF1; NbExp=4; IntAct=EBI-347677, EBI-2129250; SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P62837
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000209 protein polyubiquitination GO:0006464 cellular protein modification process GO:0006511 ubiquitin-dependent protein catabolic process GO:0006625 protein targeting to peroxisome GO:0016567 protein ubiquitination GO:0051865 protein autoubiquitination GO:0070936 protein K48-linked ubiquitination
US Server
