Human Gene SLC15A3 (ENST00000227880.8) from GENCODE V38
  Description: Homo sapiens solute carrier family 15 member 3 (SLC15A3), transcript variant 1, mRNA. (from RefSeq NM_016582)
Gencode Transcript: ENST00000227880.8
Gencode Gene: ENSG00000110446.12
Transcript (Including UTRs)
   Position: hg38 chr11:60,937,084-60,952,176 Size: 15,093 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg38 chr11:60,937,219-60,951,551 Size: 14,333 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2021-09-27 09:51:20

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr11:60,937,084-60,952,176)mRNA (may differ from genome)Protein (581 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Solute carrier family 15 member 3; AltName: Full=Osteoclast transporter; AltName: Full=Peptide transporter 3; AltName: Full=Peptide/histidine transporter 2;
FUNCTION: Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides (By similarity).
SUBCELLULAR LOCATION: Lysosome membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the PTR2/POT transporter (TC 2.A.17) family.

-  MalaCards Disease Associations
  MalaCards Gene Search: SLC15A3
Diseases sorted by gene-association score: diabetes mellitus, permanent neonatal (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 42.71 RPKM in Spleen
Total median expression: 480.85 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -154.60625-0.247 Picture PostScript Text
3' UTR -29.90135-0.221 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR016196 - MFS_dom_general_subst_transpt
IPR000109 - POT_fam

Pfam Domains:
PF00854 - POT family

ModBase Predicted Comparative 3D Structure on Q8IY34
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0015293 symporter activity
GO:0015333 peptide:proton symporter activity
GO:0022857 transmembrane transporter activity

Biological Process:
GO:0006811 ion transport
GO:0015031 protein transport
GO:0015833 peptide transport
GO:0055085 transmembrane transport
GO:1902600 hydrogen ion transmembrane transport

Cellular Component:
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle

-  Descriptions from all associated GenBank mRNAs
  BC037974 - Homo sapiens solute carrier family 15, member 3, mRNA (cDNA clone MGC:46085 IMAGE:5213632), complete cds.
BC025710 - Homo sapiens solute carrier family 15, member 3, mRNA (cDNA clone MGC:34324 IMAGE:5224878), complete cds.
AF135600 - Homo sapiens osteoclast transporter hOCTP (OCTP) mRNA, complete cds.
AB020598 - Homo sapiens mRNA for peptide transporter 3, complete cds.
AK127216 - Homo sapiens cDNA FLJ45283 fis, clone BRHIP3001878, highly similar to Homo sapiens peptide transporter 3 (PHT2).
AK130141 - Homo sapiens cDNA FLJ26631 fis, clone MPC06518, highly similar to Homo sapiens peptide transporter 3 (PHT2).
JD192251 - Sequence 173275 from Patent EP1572962.
JD180019 - Sequence 161043 from Patent EP1572962.
JD179648 - Sequence 160672 from Patent EP1572962.
JD138862 - Sequence 119886 from Patent EP1572962.
JD409563 - Sequence 390587 from Patent EP1572962.
JD038618 - Sequence 19642 from Patent EP1572962.
JD215711 - Sequence 196735 from Patent EP1572962.
JD373299 - Sequence 354323 from Patent EP1572962.
JD045362 - Sequence 26386 from Patent EP1572962.
JD328548 - Sequence 309572 from Patent EP1572962.
JD243515 - Sequence 224539 from Patent EP1572962.
JD343238 - Sequence 324262 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8IY34 (Reactome details) participates in the following event(s):

R-HSA-428007 Proton-coupled histidine and di-peptide cotransport
R-HSA-427975 Proton/oligopeptide cotransporters
R-HSA-425374 Amino acid and oligopeptide SLC transporters
R-HSA-425393 Metabolism of nitrogenous molecules
R-HSA-425407 SLC-mediated transmembrane transport
R-HSA-382551 Transport of small molecules

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000227880.1, ENST00000227880.2, ENST00000227880.3, ENST00000227880.4, ENST00000227880.5, ENST00000227880.6, ENST00000227880.7, NM_016582, OCTP, PHT2, PTR3, Q8IY34, Q9P2X9, S15A3_HUMAN, uc001nqn.1, uc001nqn.2, uc001nqn.3, uc001nqn.4
UCSC ID: ENST00000227880.8
RefSeq Accession: NM_016582
Protein: Q8IY34 (aka S15A3_HUMAN)
CCDS: CCDS7998.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.