Human Gene SLC15A3 (ENST00000227880.8) from GENCODE V38
  Description: Homo sapiens solute carrier family 15 member 3 (SLC15A3), transcript variant 1, mRNA. (from RefSeq NM_016582)
Gencode Transcript: ENST00000227880.8
Gencode Gene: ENSG00000110446.12
Transcript (Including UTRs)
   Position: hg38 chr11:60,937,084-60,952,176 Size: 15,093 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg38 chr11:60,937,219-60,951,551 Size: 14,333 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2021-09-27 09:51:20

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:60,937,084-60,952,176)mRNA (may differ from genome)Protein (581 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
ReactomeUniProtKB

-  Comments and Description Text from UniProtKB
  ID: S15A3_HUMAN
DESCRIPTION: RecName: Full=Solute carrier family 15 member 3; AltName: Full=Osteoclast transporter; AltName: Full=Peptide transporter 3; AltName: Full=Peptide/histidine transporter 2;
FUNCTION: Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides (By similarity).
SUBCELLULAR LOCATION: Lysosome membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the PTR2/POT transporter (TC 2.A.17) family.

-  MalaCards Disease Associations
  MalaCards Gene Search: SLC15A3
Diseases sorted by gene-association score: diabetes mellitus, permanent neonatal (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 42.71 RPKM in Spleen
Total median expression: 480.85 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -154.60625-0.247 Picture PostScript Text
3' UTR -29.90135-0.221 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR016196 - MFS_dom_general_subst_transpt
IPR000109 - POT_fam

Pfam Domains:
PF00854 - POT family

ModBase Predicted Comparative 3D Structure on Q8IY34
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0015293 symporter activity
GO:0015333 peptide:proton symporter activity
GO:0022857 transmembrane transporter activity

Biological Process:
GO:0006811 ion transport
GO:0015031 protein transport
GO:0015833 peptide transport
GO:0055085 transmembrane transport
GO:1902600 hydrogen ion transmembrane transport

Cellular Component:
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle


-  Descriptions from all associated GenBank mRNAs
  BC037974 - Homo sapiens solute carrier family 15, member 3, mRNA (cDNA clone MGC:46085 IMAGE:5213632), complete cds.
BC025710 - Homo sapiens solute carrier family 15, member 3, mRNA (cDNA clone MGC:34324 IMAGE:5224878), complete cds.
AF135600 - Homo sapiens osteoclast transporter hOCTP (OCTP) mRNA, complete cds.
AB020598 - Homo sapiens mRNA for peptide transporter 3, complete cds.
AK127216 - Homo sapiens cDNA FLJ45283 fis, clone BRHIP3001878, highly similar to Homo sapiens peptide transporter 3 (PHT2).
AK130141 - Homo sapiens cDNA FLJ26631 fis, clone MPC06518, highly similar to Homo sapiens peptide transporter 3 (PHT2).
JD192251 - Sequence 173275 from Patent EP1572962.
JD180019 - Sequence 161043 from Patent EP1572962.
JD179648 - Sequence 160672 from Patent EP1572962.
JD138862 - Sequence 119886 from Patent EP1572962.
JD409563 - Sequence 390587 from Patent EP1572962.
JD038618 - Sequence 19642 from Patent EP1572962.
JD215711 - Sequence 196735 from Patent EP1572962.
JD373299 - Sequence 354323 from Patent EP1572962.
JD045362 - Sequence 26386 from Patent EP1572962.
JD328548 - Sequence 309572 from Patent EP1572962.
JD243515 - Sequence 224539 from Patent EP1572962.
JD343238 - Sequence 324262 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8IY34 (Reactome details) participates in the following event(s):

R-HSA-428007 Proton-coupled histidine and di-peptide cotransport
R-HSA-427975 Proton/oligopeptide cotransporters
R-HSA-425374 Amino acid and oligopeptide SLC transporters
R-HSA-425393 Metabolism of nitrogenous molecules
R-HSA-425407 SLC-mediated transmembrane transport
R-HSA-382551 Transport of small molecules

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000227880.1, ENST00000227880.2, ENST00000227880.3, ENST00000227880.4, ENST00000227880.5, ENST00000227880.6, ENST00000227880.7, NM_016582, OCTP, PHT2, PTR3, Q8IY34, Q9P2X9, S15A3_HUMAN, uc001nqn.1, uc001nqn.2, uc001nqn.3, uc001nqn.4
UCSC ID: ENST00000227880.8
RefSeq Accession: NM_016582
Protein: Q8IY34 (aka S15A3_HUMAN)
CCDS: CCDS7998.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.