Human Gene PDE4B (ENST00000329654.8) from GENCODE V38
Description: Homo sapiens phosphodiesterase 4B (PDE4B), transcript variant e, mRNA. (from RefSeq NM_001297440) RefSeq Summary (NM_001037341): This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]. Gencode Transcript: ENST00000329654.8 Gencode Gene: ENSG00000184588.18 Transcript (Including UTRs) Position: hg38 chr1:65,792,514-66,374,278 Size: 581,765 Total Exon Count: 17 Strand: + Coding Region Position: hg38 chr1:65,913,315-66,372,678 Size: 459,364 Coding Exon Count: 16
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.