Human Gene KANK4 (ENST00000354381.3) from GENCODE V38
  Description: Homo sapiens KN motif and ankyrin repeat domains 4 (KANK4), transcript variant 2, mRNA. (from RefSeq NM_001320269)
Gencode Transcript: ENST00000354381.3
Gencode Gene: ENSG00000132854.19
Transcript (Including UTRs)
   Position: hg38 chr1:62,237,544-62,319,301 Size: 81,758 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg38 chr1:62,238,277-62,281,564 Size: 43,288 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2021-09-27 09:51:20

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:62,237,544-62,319,301)mRNA (may differ from genome)Protein (367 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
UniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: KANK4_HUMAN
DESCRIPTION: RecName: Full=KN motif and ankyrin repeat domain-containing protein 4; AltName: Full=Ankyrin repeat domain-containing protein 38;
FUNCTION: May be involved in the control of cytoskeleton formation by regulating actin polymerization.
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Strongly expressed in colon, liver, lung, skeletal muscle and kidney.
SIMILARITY: Contains 5 ANK repeats.

-  MalaCards Disease Associations
  MalaCards Gene Search: KANK4
Diseases sorted by gene-association score: nephrotic syndrome, kank4-related* (100)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 12.05 RPKM in Nerve - Tibial
Total median expression: 29.42 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -124.60266-0.468 Picture PostScript Text
3' UTR -215.10733-0.293 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002110 - Ankyrin_rpt
IPR020683 - Ankyrin_rpt-contain_dom
IPR021939 - KN_motif

Pfam Domains:
PF12796 - Ankyrin repeats (3 copies)
PF12075 - KN motif

ModBase Predicted Comparative 3D Structure on Q5T7N3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0015630 microtubule cytoskeleton


-  Descriptions from all associated GenBank mRNAs
  AK096259 - Homo sapiens cDNA FLJ38940 fis, clone NT2NE2015860, weakly similar to Erythroid ankyrin.
BC033147 - Homo sapiens KN motif and ankyrin repeat domains 4, mRNA (cDNA clone IMAGE:4122850), with apparent retained intron.
AB284127 - Homo sapiens Kank4 mRNA for kidney ankyrin repeat-containing protein 4, complete cds.
BC060866 - Homo sapiens KN motif and ankyrin repeat domains 4, mRNA (cDNA clone MGC:71814 IMAGE:30344114), complete cds.
AL832644 - Homo sapiens mRNA; cDNA DKFZp451K0518 (from clone DKFZp451K0518).
BC041418 - Homo sapiens KN motif and ankyrin repeat domains 4, mRNA (cDNA clone IMAGE:3445545), partial cds.
AK127461 - Homo sapiens cDNA FLJ45553 fis, clone BRTHA2038345, highly similar to Ankyrin repeat domain-containing protein 38.
AK091941 - Homo sapiens cDNA FLJ34622 fis, clone KIDNE2014978, weakly similar to NG28.
AX747268 - Sequence 793 from Patent EP1308459.
KJ900360 - Synthetic construct Homo sapiens clone ccsbBroadEn_09754 KANK4 gene, encodes complete protein.
JD535092 - Sequence 516116 from Patent EP1572962.
JD301863 - Sequence 282887 from Patent EP1572962.
JD210835 - Sequence 191859 from Patent EP1572962.
JD100740 - Sequence 81764 from Patent EP1572962.
JD477006 - Sequence 458030 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ANKRD38, B1ALP7, ENST00000354381.1, ENST00000354381.2, KANK4_HUMAN, NM_001320269, Q5T7N3, Q6P9A0, Q86T71, Q86VE6, Q8NAX3, uc001dai.1, uc001dai.2, uc001dai.3, uc001dai.4, uc001dai.5
UCSC ID: ENST00000354381.3
RefSeq Accession: NM_001320269
Protein: Q5T7N3 (aka KANK4_HUMAN)
CCDS: CCDS81334.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.