Human Gene CDC14A (ENST00000361544.11) from GENCODE V38
  Description: Homo sapiens cell division cycle 14A (CDC14A), transcript variant 2, mRNA. (from RefSeq NM_033312)
RefSeq Summary (NM_033312): The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000361544.11
Gencode Gene: ENSG00000079335.20
Transcript (Including UTRs)
   Position: hg38 chr1:100,352,467-100,499,465 Size: 146,999 Total Exon Count: 15 Strand: +
Coding Region
   Position: hg38 chr1:100,352,955-100,499,379 Size: 146,425 Coding Exon Count: 15 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2021-09-27 09:51:20

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:100,352,467-100,499,465)mRNA (may differ from genome)Protein (623 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
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HPRDLynxMGIneXtProtOMIMPubMed
ReactomeUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: CC14A_HUMAN
DESCRIPTION: RecName: Full=Dual specificity protein phosphatase CDC14A; EC=3.1.3.16; EC=3.1.3.48; AltName: Full=CDC14 cell division cycle 14 homolog A;
FUNCTION: Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC- FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis.
CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein + phosphate.
SUBUNIT: Interacts with KIF20A, which is required to localize CDC14 to the midzone of the mitotic spindle.
SUBCELLULAR LOCATION: Nucleus. Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Centrosomal during interphase, released into the cytoplasm at the onset of mitosis. Subsequently localizes to the midzone of the mitotic spindle.
DOMAIN: Composed of two structurally equivalent A and B domains that adopt a dual specificity protein phosphatase (DSP) fold (By similarity).
SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.
SEQUENCE CAUTION: Sequence=AAB88277.1; Type=Frameshift; Positions=6;
WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/cdc14a/";

-  MalaCards Disease Associations
  MalaCards Gene Search: CDC14A
Diseases sorted by gene-association score: deafness, autosomal recessive 105* (919), autosomal recessive non-syndromic sensorineural deafness type dfnb* (51)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.13 RPKM in Testis
Total median expression: 95.94 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -235.00488-0.482 Picture PostScript Text
3' UTR -9.9086-0.115 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000340 - Dual-sp_phosphatase_cat-dom
IPR020422 - Dual-sp_phosphatase_subgr_cat
IPR026068 - Dual_Pase_CDC14
IPR000387 - Tyr/Dual-specificity_Pase
IPR016130 - Tyr_Pase_AS

Pfam Domains:
PF00782 - Dual specificity phosphatase, catalytic domain

ModBase Predicted Comparative 3D Structure on Q9UNH5
FrontTopSide
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl WormBase 
Protein SequenceProtein Sequence  Protein Sequence 
AlignmentAlignment  Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity

Biological Process:
GO:0006470 protein dephosphorylation
GO:0007049 cell cycle
GO:0007096 regulation of exit from mitosis
GO:0008283 cell proliferation
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0051256 mitotic spindle midzone assembly
GO:0051301 cell division
GO:0060271 cilium assembly
GO:0071850 mitotic cell cycle arrest

Cellular Component:
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005815 microtubule organizing center
GO:0005819 spindle
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0016604 nuclear body
GO:0042995 cell projection
GO:0060091 kinocilium
GO:0072686 mitotic spindle


-  Descriptions from all associated GenBank mRNAs
  AK302310 - Homo sapiens cDNA FLJ57230 complete cds, highly similar to Dual specificity protein phosphatase CDC14A(EC 3.1.3.48).
AK310292 - Homo sapiens cDNA, FLJ17334.
AF064102 - Homo sapiens Cdc14A2 phosphatase mRNA, complete cds.
BC071578 - Homo sapiens cDNA clone IMAGE:5258923, containing frame-shift errors.
AF064103 - Homo sapiens Cdc14A3 phosphatase mRNA, complete cds.
AF000367 - Homo sapiens cdc14 homolog mRNA, complete cds.
BC093916 - Homo sapiens CDC14 cell division cycle 14 homolog A (S. cerevisiae), mRNA (cDNA clone MGC:120951 IMAGE:7939761), complete cds.
BC093918 - Homo sapiens CDC14 cell division cycle 14 homolog A (S. cerevisiae), mRNA (cDNA clone MGC:120953 IMAGE:7939763), complete cds.
BC038979 - Homo sapiens CDC14 cell division cycle 14 homolog A (S. cerevisiae), mRNA (cDNA clone IMAGE:5741885), complete cds.
DQ530256 - Homo sapiens CDC14A variant 4 mRNA, complete cds, alternatively spliced.
KJ892560 - Synthetic construct Homo sapiens clone ccsbBroadEn_01954 CDC14A gene, encodes complete protein.
AF122013 - Homo sapiens dual-specificity phosphatase (CDC14A) mRNA, complete cds.
AB209857 - Homo sapiens mRNA for CDC14 homolog A isoform 1 variant protein.
AK310657 - Homo sapiens cDNA, FLJ17699.
JD102836 - Sequence 83860 from Patent EP1572962.
JD468470 - Sequence 449494 from Patent EP1572962.
JD134030 - Sequence 115054 from Patent EP1572962.
JD420868 - Sequence 401892 from Patent EP1572962.
JD458629 - Sequence 439653 from Patent EP1572962.
JD129363 - Sequence 110387 from Patent EP1572962.
JD406523 - Sequence 387547 from Patent EP1572962.
JD400163 - Sequence 381187 from Patent EP1572962.
JD256954 - Sequence 237978 from Patent EP1572962.
JD215453 - Sequence 196477 from Patent EP1572962.
JD401309 - Sequence 382333 from Patent EP1572962.
JD275863 - Sequence 256887 from Patent EP1572962.
JD387528 - Sequence 368552 from Patent EP1572962.
JD231346 - Sequence 212370 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04110 - Cell cycle

Reactome (by CSHL, EBI, and GO)

Protein Q9UNH5 (Reactome details) participates in the following event(s):

R-HSA-5692749 CDC14A,B bind MAPK6
R-HSA-174124 Dephosphorylation of phospho-Cdh1
R-HSA-5692754 CDC14A,B dephosphorylate p-3S,T MAPK6
R-HSA-5687128 MAPK6/MAPK4 signaling
R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
R-HSA-5683057 MAPK family signaling cascades
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins
R-HSA-162582 Signal Transduction
R-HSA-453276 Regulation of mitotic cell cycle
R-HSA-69278 Cell Cycle (Mitotic)
R-HSA-1640170 Cell Cycle

-  Other Names for This Gene
  Alternate Gene Symbols: B1AQ14, B1AQ15, CC14A_HUMAN, ENST00000361544.1, ENST00000361544.10, ENST00000361544.2, ENST00000361544.3, ENST00000361544.4, ENST00000361544.5, ENST00000361544.6, ENST00000361544.7, ENST00000361544.8, ENST00000361544.9, NM_033312, O43171, O60727, O60728, Q52LH9, Q8IXX0, Q9UNH5, uc001dtf.1, uc001dtf.2, uc001dtf.3, uc001dtf.4
UCSC ID: ENST00000361544.11
RefSeq Accession: NM_033312
Protein: Q9UNH5 (aka CC14A_HUMAN)
CCDS: CCDS770.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.