Human Gene KANK4 (ENST00000371150.5) from GENCODE V38
  Description: KN motif and ankyrin repeat domains 4 (from HGNC KANK4)
Gencode Transcript: ENST00000371150.5
Gencode Gene: ENSG00000132854.19
Transcript (Including UTRs)
   Position: hg38 chr1:62,237,544-62,272,791 Size: 35,248 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg38 chr1:62,238,277-62,271,557 Size: 33,281 Coding Exon Count: 7 

Page IndexSequence and LinksMalaCardsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2021-09-27 09:51:20

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:62,237,544-62,272,791)mRNA (may differ from genome)Protein (351 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS

-  MalaCards Disease Associations
  MalaCards Gene Search: KANK4
Diseases sorted by gene-association score: nephrotic syndrome, kank4-related* (100)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 12.05 RPKM in Nerve - Tibial
Total median expression: 29.42 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -411.001234-0.333 Picture PostScript Text
3' UTR -215.10733-0.293 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002110 - Ankyrin_rpt
IPR020683 - Ankyrin_rpt-contain_dom

Pfam Domains:
PF12796 - Ankyrin repeats (3 copies)

ModBase Predicted Comparative 3D Structure on B1ALP6
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Descriptions from all associated GenBank mRNAs
  AK096259 - Homo sapiens cDNA FLJ38940 fis, clone NT2NE2015860, weakly similar to Erythroid ankyrin.
BC033147 - Homo sapiens KN motif and ankyrin repeat domains 4, mRNA (cDNA clone IMAGE:4122850), with apparent retained intron.
AB284127 - Homo sapiens Kank4 mRNA for kidney ankyrin repeat-containing protein 4, complete cds.
BC060866 - Homo sapiens KN motif and ankyrin repeat domains 4, mRNA (cDNA clone MGC:71814 IMAGE:30344114), complete cds.
AL832644 - Homo sapiens mRNA; cDNA DKFZp451K0518 (from clone DKFZp451K0518).
BC041418 - Homo sapiens KN motif and ankyrin repeat domains 4, mRNA (cDNA clone IMAGE:3445545), partial cds.
AK127461 - Homo sapiens cDNA FLJ45553 fis, clone BRTHA2038345, highly similar to Ankyrin repeat domain-containing protein 38.
AK091941 - Homo sapiens cDNA FLJ34622 fis, clone KIDNE2014978, weakly similar to NG28.
AX747268 - Sequence 793 from Patent EP1308459.
KJ900360 - Synthetic construct Homo sapiens clone ccsbBroadEn_09754 KANK4 gene, encodes complete protein.
JD535092 - Sequence 516116 from Patent EP1572962.
JD301863 - Sequence 282887 from Patent EP1572962.
JD210835 - Sequence 191859 from Patent EP1572962.
JD100740 - Sequence 81764 from Patent EP1572962.
JD477006 - Sequence 458030 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AK127461, B1ALP6, B1ALP6_HUMAN, ENST00000371150.1, ENST00000371150.2, ENST00000371150.3, ENST00000371150.4, RP5-1155K23.5-003, uc001dag.1, uc001dag.2, uc001dag.3, uc001dag.4, uc001dag.5
UCSC ID: ENST00000371150.5
RefSeq Accession: NM_001320269
Protein: B1ALP6 CCDS: CCDS81334.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.