Human Gene SNCG (ENST00000372017.4) from GENCODE V38
  Description: Homo sapiens synuclein gamma (SNCG), transcript variant 1, mRNA. (from RefSeq NM_003087)
RefSeq Summary (NM_003087): This gene encodes a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. Mutations in this gene have also been associated with breast tumor development. [provided by RefSeq, Jan 2010].
Gencode Transcript: ENST00000372017.4
Gencode Gene: ENSG00000173267.14
Transcript (Including UTRs)
   Position: hg38 chr10:86,958,599-86,963,258 Size: 4,660 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg38 chr10:86,958,698-86,962,985 Size: 4,288 Coding Exon Count: 5 

Page IndexSequence and LinksMalaCardsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Data last updated at UCSC: 2021-09-27 09:51:20

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr10:86,958,599-86,963,258)mRNA (may differ from genome)Protein (127 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC

-  MalaCards Disease Associations
  MalaCards Gene Search: SNCG
Diseases sorted by gene-association score: breast cancer (7), synucleinopathy (4), dementia, lewy body (3), parkinson disease, late-onset (3), ovarian cancer, somatic (2), movement disease (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 237.10 RPKM in Brain - Hypothalamus
Total median expression: 2049.78 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -33.9099-0.342 Picture PostScript Text
3' UTR -73.40273-0.269 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001058 - Synuclein
IPR002462 - Synuclein_gamma

Pfam Domains:
PF01387 - Synuclein

ModBase Predicted Comparative 3D Structure on Q6FHG5
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0007268 chemical synaptic transmission
GO:0008344 adult locomotory behavior
GO:0009306 protein secretion
GO:0014059 regulation of dopamine secretion
GO:0046928 regulation of neurotransmitter secretion
GO:0050808 synapse organization

Cellular Component:
GO:0005737 cytoplasm
GO:0030424 axon
GO:0043025 neuronal cell body

-  Descriptions from all associated GenBank mRNAs
  LF210007 - JP 2014500723-A/17510: Polycomb-Associated Non-Coding RNAs.
MA445584 - JP 2018138019-A/17510: Polycomb-Associated Non-Coding RNAs.
AK223367 - Homo sapiens mRNA for synuclein, gamma (breast cancer-specific protein 1) variant, clone: FCC102C09.
AK311652 - Homo sapiens cDNA, FLJ18694.
BC014098 - Homo sapiens synuclein, gamma (breast cancer-specific protein 1), mRNA (cDNA clone MGC:20132 IMAGE:4546444), complete cds.
AK312141 - Homo sapiens cDNA, FLJ92424, highly similar to Homo sapiens synuclein, gamma (breast cancer-specific protein 1) (SNCG), mRNA.
AF017256 - Homo sapiens persyn mRNA, complete cds.
AF411524 - Homo sapiens synuclein gamma mRNA, complete cds.
EU019993 - Homo sapiens gamma-synuclein (SNCG) mRNA, complete cds, alternatively spliced.
DQ895719 - Synthetic construct Homo sapiens clone IMAGE:100010179; FLH186973.01L; RZPDo839C0662D synuclein, gamma (breast cancer-specific protein 1) (SNCG) gene, encodes complete protein.
EU176715 - Synthetic construct Homo sapiens clone IMAGE:100011575; FLH263602.01L; RZPDo839C1273D synuclein, gamma (breast cancer-specific protein 1) (SNCG) gene, encodes complete protein.
DQ892334 - Synthetic construct Homo sapiens clone IMAGE:100004964; FLH263510.01X; RZPDo839B01148D synuclein, gamma (breast cancer-specific protein 1) (SNCG) gene, encodes complete protein.
DQ892505 - Synthetic construct clone IMAGE:100005135; FLH186977.01X; RZPDo839C0672D synuclein, gamma (breast cancer-specific protein 1) (SNCG) gene, encodes complete protein.
AF010126 - Homo sapiens breast cancer-specific protein 1 (BCSG1) mRNA, complete cds.
AB464279 - Synthetic construct DNA, clone: pF1KB6793, Homo sapiens SNCG gene for synuclein, gamma, without stop codon, in Flexi system.
KJ892170 - Synthetic construct Homo sapiens clone ccsbBroadEn_01564 SNCG gene, encodes complete protein.
CR541790 - Homo sapiens full open reading frame cDNA clone RZPDo834B0231D for gene SNCG, synuclein, gamma (breast cancer-specific protein 1); complete cds, without stopcodon.
CR541788 - Homo sapiens full open reading frame cDNA clone RZPDo834F0930D for gene SNCG, synuclein, gamma (breast cancer-specific protein 1); complete cds, incl. stopcodon.
LF333954 - JP 2014500723-A/141457: Polycomb-Associated Non-Coding RNAs.
MA569531 - JP 2018138019-A/141457: Polycomb-Associated Non-Coding RNAs.
JD544263 - Sequence 525287 from Patent EP1572962.
JD483937 - Sequence 464961 from Patent EP1572962.
JD237375 - Sequence 218399 from Patent EP1572962.
JD207057 - Sequence 188081 from Patent EP1572962.
JD507941 - Sequence 488965 from Patent EP1572962.
JD392025 - Sequence 373049 from Patent EP1572962.
JD116381 - Sequence 97405 from Patent EP1572962.
JD451373 - Sequence 432397 from Patent EP1572962.
JD210163 - Sequence 191187 from Patent EP1572962.
JD365363 - Sequence 346387 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A6NM47, ENST00000372017.1, ENST00000372017.2, ENST00000372017.3, hCG_23263, NM_003087, Q6FHG5, Q6FHG5_HUMAN, uc001keb.1, uc001keb.2, uc001keb.3, uc001keb.4
UCSC ID: ENST00000372017.4
RefSeq Accession: NM_003087
Protein: Q6FHG5 CCDS: CCDS7380.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.