Human Gene EIF4G3 (ENST00000400422.6) from GENCODE V38
Description: Homo sapiens eukaryotic translation initiation factor 4 gamma 3 (EIF4G3), transcript variant 1, mRNA. (from RefSeq NM_001198801) RefSeq Summary (NM_001198801): The protein encoded by this gene is thought to be part of the eIF4F protein complex, which is involved in mRNA cap recognition and transport of mRNAs to the ribosome. Interestingly, a microRNA (miR-520c-3p) has been found that negatively regulates synthesis of the encoded protein, and this leads to a global decrease in protein translation and cell proliferation. Therefore, this protein is a key component of the anti-tumor activity of miR-520c-3p. [provided by RefSeq, May 2016]. Gencode Transcript: ENST00000400422.6 Gencode Gene: ENSG00000075151.23 Transcript (Including UTRs) Position: hg38 chr1:20,807,004-21,176,847 Size: 369,844 Total Exon Count: 35 Strand: - Coding Region Position: hg38 chr1:20,807,319-21,002,742 Size: 195,424 Coding Exon Count: 31
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.