Human Gene FGD4 (ENST00000472289.5) from GENCODE V38
Description: Homo sapiens FYVE, RhoGEF and PH domain containing 4 (FGD4), transcript variant 15, mRNA. (from RefSeq NM_001384132) RefSeq Summary (NM_001384131): This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Gencode Transcript: ENST00000472289.5 Gencode Gene: ENSG00000139132.16 Transcript (Including UTRs) Position: hg38 chr12:32,502,043-32,582,955 Size: 80,913 Total Exon Count: 4 Strand: + Coding Region Position: hg38 chr12:32,576,358-32,582,491 Size: 6,134 Coding Exon Count: 2
ID:E9PQT1_HUMAN DESCRIPTION: SubName: Full=FYVE, RhoGEF and PH domain-containing protein 4; CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
ModBase Predicted Comparative 3D Structure on E9PQT1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.