Human Gene EIF4G3 (ENST00000634879.2) from GENCODE V38
  Description: eukaryotic translation initiation factor 4 gamma 3 (from HGNC EIF4G3)
RefSeq Summary (NM_001198802): The protein encoded by this gene is thought to be part of the eIF4F protein complex, which is involved in mRNA cap recognition and transport of mRNAs to the ribosome. Interestingly, a microRNA (miR-520c-3p) has been found that negatively regulates synthesis of the encoded protein, and this leads to a global decrease in protein translation and cell proliferation. Therefore, this protein is a key component of the anti-tumor activity of miR-520c-3p. [provided by RefSeq, May 2016].
Gencode Transcript: ENST00000634879.2
Gencode Gene: ENSG00000075151.23
Transcript (Including UTRs)
   Position: hg38 chr1:20,807,319-21,176,836 Size: 369,518 Total Exon Count: 34 Strand: -
Coding Region
   Position: hg38 chr1:20,807,319-21,176,836 Size: 369,518 Coding Exon Count: 34 

Page IndexSequence and LinksCTDRNA-Seq ExpressionMicroarray ExpressionOther Species
mRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2021-09-27 09:51:20

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:20,807,319-21,176,836)mRNA (may differ from genome)Protein (1774 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblExonPrimerGeneCardsHGNCLynx
MGIPubMedUniProtKBWikipedia

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 44.17 RPKM in Testis
Total median expression: 592.78 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserGenome BrowserGenome Browser
Gene Details    Gene Details
Gene Sorter    Gene Sorter
MGIRGD EnsemblWormBaseSGD
Protein SequenceProtein Sequence Protein SequenceProtein SequenceProtein Sequence
AlignmentAlignment AlignmentAlignmentAlignment

-  Descriptions from all associated GenBank mRNAs
  AF012072 - Homo sapiens eIF4GII mRNA, complete cds.
AB209119 - Homo sapiens mRNA for eukaryotic translation initiation factor 4 gamma, 3 variant protein.
BC094683 - Homo sapiens eukaryotic translation initiation factor 4 gamma, 3, mRNA (cDNA clone MGC:102792 IMAGE:6188273), complete cds.
BC072413 - Homo sapiens eukaryotic translation initiation factor 4 gamma, 3, mRNA (cDNA clone IMAGE:6165611), partial cds.
BC136643 - Homo sapiens eukaryotic translation initiation factor 4 gamma, 3, mRNA (cDNA clone MGC:168256 IMAGE:9020633), complete cds.
BC144335 - Homo sapiens cDNA clone IMAGE:9052855, containing frame-shift errors.
AK294883 - Homo sapiens cDNA FLJ59298 complete cds, highly similar to Eukaryotic translation initiation factor 4 gamma 3.
AK225489 - Homo sapiens mRNA for Splice isoform 2 of O43432 variant, clone: JTH03575.
BC030578 - Homo sapiens eukaryotic translation initiation factor 4 gamma, 3, mRNA (cDNA clone IMAGE:4836870), complete cds.
AK302087 - Homo sapiens cDNA FLJ60945 complete cds, highly similar to Eukaryotic translation initiation factor 4gamma 3.
AK302873 - Homo sapiens cDNA FLJ53944 complete cds, highly similar to Eukaryotic translation initiation factor 4 gamma 3.
Z34918 - H.sapiens mRNA for translation initiation factor eIF-4gamma (partial).
JD102602 - Sequence 83626 from Patent EP1572962.
AK310195 - Homo sapiens cDNA, FLJ17237.
BX647897 - Homo sapiens mRNA; cDNA DKFZp686C17112 (from clone DKFZp686C17112).
JD244587 - Sequence 225611 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa05416 - Viral myocarditis

BioCarta from NCI Cancer Genome Anatomy Project
h_eif4Pathway - Regulation of eIF4e and p70 S6 Kinase
h_eifPathway - Eukaryotic protein translation
h_mTORPathway - mTOR Signaling Pathway
h_iresPathway - Internal Ribosome entry pathway

-  Other Names for This Gene
  Alternate Gene Symbols: A0A0U1RQK7, BC072413, ENST00000634879.1, uc284mng.1, uc284mng.2
UCSC ID: ENST00000634879.2
RefSeq Accession: NM_001198802

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.