Human Gene EIF4G3 (ENST00000634879.2) from GENCODE V38
Description: eukaryotic translation initiation factor 4 gamma 3 (from HGNC EIF4G3) RefSeq Summary (NM_001198802): The protein encoded by this gene is thought to be part of the eIF4F protein complex, which is involved in mRNA cap recognition and transport of mRNAs to the ribosome. Interestingly, a microRNA (miR-520c-3p) has been found that negatively regulates synthesis of the encoded protein, and this leads to a global decrease in protein translation and cell proliferation. Therefore, this protein is a key component of the anti-tumor activity of miR-520c-3p. [provided by RefSeq, May 2016]. Gencode Transcript: ENST00000634879.2 Gencode Gene: ENSG00000075151.23 Transcript (Including UTRs) Position: hg38 chr1:20,807,319-21,176,836 Size: 369,518 Total Exon Count: 34 Strand: - Coding Region Position: hg38 chr1:20,807,319-21,176,836 Size: 369,518 Coding Exon Count: 34
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.