Human Gene CDC14A (ENST00000635056.2) from GENCODE V38
Description: Homo sapiens cell division cycle 14A (CDC14A), transcript variant 6, mRNA. (from RefSeq NM_001319212) RefSeq Summary (NM_001319211): The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000635056.2 Gencode Gene: ENSG00000079335.20 Transcript (Including UTRs) Position: hg38 chr1:100,345,022-100,499,453 Size: 154,432 Total Exon Count: 15 Strand: + Coding Region Position: hg38 chr1:100,377,580-100,499,379 Size: 121,800 Coding Exon Count: 13
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.