Human Gene CDC14A (ENST00000644676.1) from GENCODE V38
  Description: cell division cycle 14A (from HGNC CDC14A)
RefSeq Summary (NM_001319211): The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000644676.1
Gencode Gene: ENSG00000079335.20
Transcript (Including UTRs)
   Position: hg38 chr1:100,351,698-100,499,460 Size: 147,763 Total Exon Count: 15 Strand: +
Coding Region
   Position: hg38 chr1:100,351,757-100,499,379 Size: 147,623 Coding Exon Count: 15 

Page IndexSequence and LinksMalaCardsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureOther SpeciesmRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2021-09-27 09:51:20

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:100,351,698-100,499,460)mRNA (may differ from genome)Protein (624 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblExonPrimerGeneCardsHGNCLynx
MGIPubMedUniProtKBWikipedia

-  MalaCards Disease Associations
  MalaCards Gene Search: CDC14A
Diseases sorted by gene-association score: deafness, autosomal recessive 105* (919), autosomal recessive non-syndromic sensorineural deafness type dfnb* (51)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.13 RPKM in Testis
Total median expression: 95.94 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -17.4059-0.295 Picture PostScript Text
3' UTR -7.6081-0.094 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Descriptions from all associated GenBank mRNAs
  AK302310 - Homo sapiens cDNA FLJ57230 complete cds, highly similar to Dual specificity protein phosphatase CDC14A(EC 3.1.3.48).
AK310292 - Homo sapiens cDNA, FLJ17334.
AF064102 - Homo sapiens Cdc14A2 phosphatase mRNA, complete cds.
BC071578 - Homo sapiens cDNA clone IMAGE:5258923, containing frame-shift errors.
AF064103 - Homo sapiens Cdc14A3 phosphatase mRNA, complete cds.
AF000367 - Homo sapiens cdc14 homolog mRNA, complete cds.
BC093916 - Homo sapiens CDC14 cell division cycle 14 homolog A (S. cerevisiae), mRNA (cDNA clone MGC:120951 IMAGE:7939761), complete cds.
BC093918 - Homo sapiens CDC14 cell division cycle 14 homolog A (S. cerevisiae), mRNA (cDNA clone MGC:120953 IMAGE:7939763), complete cds.
BC038979 - Homo sapiens CDC14 cell division cycle 14 homolog A (S. cerevisiae), mRNA (cDNA clone IMAGE:5741885), complete cds.
DQ530256 - Homo sapiens CDC14A variant 4 mRNA, complete cds, alternatively spliced.
KJ892560 - Synthetic construct Homo sapiens clone ccsbBroadEn_01954 CDC14A gene, encodes complete protein.
AF122013 - Homo sapiens dual-specificity phosphatase (CDC14A) mRNA, complete cds.
AB209857 - Homo sapiens mRNA for CDC14 homolog A isoform 1 variant protein.
AK310657 - Homo sapiens cDNA, FLJ17699.
JD231346 - Sequence 212370 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04110 - Cell cycle

-  Other Names for This Gene
  Alternate Gene Symbols: A0A2R8YDJ8, AK302310, uc057iqr.1, uc057iqr.2
UCSC ID: ENST00000644676.1
RefSeq Accession: NM_001319211
CCDS: CCDS770.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.