S. cerevisiae Gene SED4 (YCR067C) Description and Page Index
  Description: Integral endoplasmic reticulum membrane protein that stimulates Sar1p GTPase activity involved in COPII vesicle budding through disassociation of coat proteins from membranes onto liposomes binds Sec16p similar to Sec12p
Transcript (Including UTRs)
   Position: sacCer3 chrIII:233,125-236,322 Size: 3,198 Total Exon Count: 1 Strand: -
Coding Region
   Position: sacCer3 chrIII:233,125-236,322 Size: 3,198 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsProtein StructureOther SpeciesGO Annotations
Other NamesMethods
Data last updated: 2011-08-29

-  Sequence and Links to Tools and Databases
Genomic Sequence (chrIII:233,125-236,322)mRNAProtein (1065 aa)
Gene SorterGenome BrowserOther Species FASTASGDUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Putative guanine nucleotide-exchange factor SED4;
FUNCTION: Putative guanine nucleotide-exchange factor (GEF) involved in the formation or budding of transport vesicles from the ER. Positive regulator of SAR1 probably through inhibition of the GTPase activation by SEC23.
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein (Potential). Note=In the process of transport, SED4 itself may migrate to the Golgi apparatus and function in subsequent transport events.
SIMILARITY: Belongs to the WD repeat SEC12 family.
SIMILARITY: Contains 2 WD repeats.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR015943 - WD40/YVTN_repeat-like_dom
IPR001680 - WD40_repeat
IPR017986 - WD40_repeat_dom

Pfam Domains:
PF00400 - WD domain, G-beta repeat

ModBase Predicted Comparative 3D Structure on P25365
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanMouseRatZebrafishD. melanogasterC. elegans
No orthologNo orthologNo orthologNo orthologGenome BrowserGenome Browser
    Gene DetailsGene Details
    Gene SorterGene Sorter
    Protein SequenceProtein Sequence

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005090 Sar guanyl-nucleotide exchange factor activity
GO:0005096 GTPase activator activity
GO:0051020 GTPase binding

Biological Process:
GO:0003400 regulation of COPII vesicle coating
GO:0009306 protein secretion
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0043547 positive regulation of GTPase activity

Cellular Component:
GO:0000139 Golgi membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030176 integral component of endoplasmic reticulum membrane

-  Other Names for This Gene
Protein: P25365 (aka SED4_YEAST)

-  SGD Genes Methods, Credits, and Data Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.