S. cerevisiae Gene ATG15 (YCR068W) Description and Page Index
  Description: Lipase required for intravacuolar lysis of autophagic bodies and Cvt bodies targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway
Transcript (Including UTRs)
   Position: sacCer3 chrIII:237,214-238,776 Size: 1,563 Total Exon Count: 1 Strand: +
Coding Region
   Position: sacCer3 chrIII:237,214-238,776 Size: 1,563 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsProtein StructureOther SpeciesGO Annotations
Other NamesMethods
Data last updated at UCSC: 2011-08-29

-  Sequence and Links to Tools and Databases
Genomic Sequence (chrIII:237,214-238,776)mRNAProtein (520 aa)
Gene SorterGenome BrowserOther Species FASTASGDUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Putative lipase ATG15; EC=; AltName: Full=Autophagy-related protein 15; AltName: Full=Cytoplasm to vacuole targeting protein 17;
FUNCTION: Essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles.
CATALYTIC ACTIVITY: Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Endosome, multivesicular body membrane; Single-pass type II membrane protein. Prevacuolar compartment membrane; Single-pass type II membrane protein. Note=From ER, targeted to vacuolar lumen at the MVB vesicles via the Golgi and the prevacuolar compartment (PVC).
PTM: Glycosylated.
MISCELLANEOUS: Present with 3060 molecules/cell in log phase SD medium.
SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002921 - Lipase_3

Pfam Domains:
PF01764 - Lipase (class 3)

ModBase Predicted Comparative 3D Structure on P25641
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanMouseRatZebrafishD. melanogasterC. elegans
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004620 phospholipase activity
GO:0004806 triglyceride lipase activity
GO:0016787 hydrolase activity

Biological Process:
GO:0006624 vacuolar protein processing
GO:0006629 lipid metabolic process
GO:0006660 phosphatidylserine catabolic process
GO:0006914 autophagy
GO:0016042 lipid catabolic process
GO:0030397 membrane disassembly
GO:0034496 multivesicular body membrane disassembly
GO:0034727 piecemeal microautophagy of nucleus
GO:0046461 neutral lipid catabolic process

Cellular Component:
GO:0000139 Golgi membrane
GO:0005768 endosome
GO:0005775 vacuolar lumen
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031902 late endosome membrane
GO:0032585 multivesicular body membrane

-  Other Names for This Gene
Protein: P25641 (aka ATG15_YEAST or AG15_YEAST)

-  SGD Genes Methods, Credits, and Data Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.