S. cerevisiae Gene CPR4 (YCR069W) Description and Page Index
  Description: Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues has a potential role in the secretory pathway
Transcript (Including UTRs)
   Position: sacCer3 chrIII:239,055-240,011 Size: 957 Total Exon Count: 1 Strand: +
Coding Region
   Position: sacCer3 chrIII:239,055-240,011 Size: 957 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsProtein StructureOther SpeciesGO Annotations
Other NamesMethods
Data last updated: 2011-08-29

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrIII:239,055-240,011)mRNAProtein (318 aa)
Gene SorterGenome BrowserOther Species FASTASGDUniProtKB

-  Comments and Description Text from UniProtKB
  ID: CYPR_YEAST
DESCRIPTION: RecName: Full=Peptidyl-prolyl cis-trans isomerase CPR4; Short=PPIase CPR4; EC=5.2.1.8; AltName: Full=Rotamase; Flags: Precursor;
FUNCTION: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
CATALYTIC ACTIVITY: Peptidylproline (omega=180) = peptidylproline (omega=0).
SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).
SIMILARITY: Contains 1 PPIase cyclophilin-type domain.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002130 - Cyclophilin-like_PPIase_dom

Pfam Domains:
PF00160 - Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD

ModBase Predicted Comparative 3D Structure on P25334
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanMouseRatZebrafishD. melanogasterC. elegans
No orthologNo orthologNo orthologNo orthologGenome BrowserGenome Browser
    Gene DetailsGene Details
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    FlyBaseWormBase
    Protein SequenceProtein Sequence
    AlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0016853 isomerase activity

Biological Process:
GO:0000413 protein peptidyl-prolyl isomerization
GO:0008150 biological_process

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Other Names for This Gene
  UCSC ID: YCR069W
Protein: P25334 (aka CYPR_YEAST)

-  SGD Genes Methods, Credits, and Data Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.