S. cerevisiae Gene RSA4 (YCR072C) Description and Page Index
  Description: WD-repeat protein involved in ribosome biogenesis may interact with ribosomes required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus
Transcript (Including UTRs)
   Position: sacCer3 chrIII:240,805-242,352 Size: 1,548 Total Exon Count: 1 Strand: -
Coding Region
   Position: sacCer3 chrIII:240,805-242,352 Size: 1,548 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsProtein StructureOther SpeciesGO Annotations
Other NamesMethods
Data last updated at UCSC: 2011-08-29

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrIII:240,805-242,352)mRNAProtein (515 aa)
Gene SorterGenome BrowserOther Species FASTASGDUniProtKB

-  Comments and Description Text from UniProtKB
  ID: NLE1_YEAST
DESCRIPTION: RecName: Full=Ribosome assembly protein 4;
FUNCTION: Involved in processing and efficient intra-nuclear transport or pre-60S ribosomal subunits. Forms a complex with REA1 which is essential for ATP-dependent dissociation of a group of nonribosomal factors from the pre-60S particle.
SUBUNIT: Associates with the pre-60S ribosomal particle. Interacts with MND1.
INTERACTION: Q12019:MDN1; NbExp=6; IntAct=EBI-21980, EBI-10633;
SUBCELLULAR LOCATION: Nucleus, nucleolus.
SIMILARITY: Belongs to the NLE1/RSA4 family.
SIMILARITY: Contains 8 WD repeats.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR020472 - G-protein_beta_WD-40_rep
IPR012972 - NLE
IPR015943 - WD40/YVTN_repeat-like_dom
IPR001680 - WD40_repeat
IPR019775 - WD40_repeat_CS
IPR017986 - WD40_repeat_dom

Pfam Domains:
PF08154 - NLE (NUC135) domain
PF00400 - WD domain, G-beta repeat

ModBase Predicted Comparative 3D Structure on P25382
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanMouseRatZebrafishD. melanogasterC. elegans
Genome BrowserNo orthologNo orthologNo orthologGenome BrowserGenome Browser
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