S. cerevisiae Gene SSK22 (YCR073C) Description and Page Index
  Description: MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway functionally redundant with, and homologous to, Ssk2p interacts with and is activated by Ssk1p phosphorylates Pbs2p
Transcript (Including UTRs)
   Position: sacCer3 chrIII:242,588-246,583 Size: 3,996 Total Exon Count: 1 Strand: -
Coding Region
   Position: sacCer3 chrIII:242,588-246,583 Size: 3,996 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsProtein StructureOther SpeciesGO Annotations
Other NamesMethods
Data last updated: 2011-08-29

-  Sequence and Links to Tools and Databases
Genomic Sequence (chrIII:242,588-246,583)mRNAProtein (1331 aa)
Gene SorterGenome BrowserOther Species FASTASGDUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Serine/threonine-protein kinase SSK22; EC=; AltName: Full=MAP kinase kinase kinase SSK22; AltName: Full=Suppressor of sensor kinase 22;
FUNCTION: Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Activates the PBS2 MAP kinase kinase by phosphorylation.
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
SUBUNIT: Interacts with by SSK1.
INTERACTION: Q07084:SSK1; NbExp=5; IntAct=EBI-18129, EBI-18184;
MISCELLANEOUS: Present with 56 molecules/cell in log phase SD medium.
SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
SIMILARITY: Contains 1 protein kinase domain.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011009 - Kinase-like_dom
IPR017240 - MAPKKK_SSK22
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR002290 - Ser/Thr_dual-sp_kinase_dom
IPR008271 - Ser/Thr_kinase_AS

Pfam Domains:
PF00069 - Protein kinase domain

ModBase Predicted Comparative 3D Structure on P25390
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanMouseRatZebrafishD. melanogasterC. elegans
No orthologNo orthologNo orthologNo orthologGenome BrowserGenome Browser
    Gene DetailsGene Details
    Gene SorterGene Sorter
    Protein SequenceProtein Sequence

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity

Biological Process:
GO:0000165 MAPK cascade
GO:0000186 activation of MAPKK activity
GO:0006468 protein phosphorylation
GO:0007346 regulation of mitotic cell cycle
GO:0016310 phosphorylation
GO:0031098 stress-activated protein kinase signaling cascade
GO:0032147 activation of protein kinase activity
GO:0042981 regulation of apoptotic process
GO:0051403 stress-activated MAPK cascade

Cellular Component:
GO:0005575 cellular_component
GO:0005737 cytoplasm

-  Other Names for This Gene
Protein: P25390 (aka SSK22_YEAST or SS22_YEAST)

-  SGD Genes Methods, Credits, and Data Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.