S. cerevisiae Gene ERG9 (YHR190W) Description and Page Index
  Description: Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway
Transcript (Including UTRs)
   Position: sacCer3 chrVIII:484,845-486,179 Size: 1,335 Total Exon Count: 1 Strand: +
Coding Region
   Position: sacCer3 chrVIII:484,845-486,179 Size: 1,335 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2011-08-29

-  Sequence and Links to Tools and Databases
Genomic Sequence (chrVIII:484,845-486,179)mRNAProtein (444 aa)
Gene SorterGenome BrowserOther Species FASTASGDUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Squalene synthase; Short=SQS; Short=SS; EC=; AltName: Full=FPP:FPP farnesyltransferase; AltName: Full=Farnesyl-diphosphate farnesyltransferase;
FUNCTION: Catalyzes the condensation of 2 two farnesyl pyrophosphate moieties to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway. Required for the biosynthesis of ergosterol. May also have a regulatory role regulating the flux of isoprene intermediates through the sterol pathway. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. ERG9 is also essential for cell growth in yeast.
CATALYTIC ACTIVITY: 2 farnesyl diphosphate + NAD(P)H = squalene + 2 diphosphate + NAD(P)(+).
COFACTOR: Magnesium.
PATHWAY: Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3.
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome.
MISCELLANEOUS: Present with 10800 molecules/cell in log phase SD medium.
SIMILARITY: Belongs to the phytoene/squalene synthase family.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002060 - Squ/phyt_synthse
IPR006449 - Squal_synth
IPR019845 - Squalene/phytoene_synthase_CS
IPR008949 - Terpenoid_synth

Pfam Domains:
PF00494 - Squalene/phytoene synthase

ModBase Predicted Comparative 3D Structure on P29704
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanMouseRatZebrafishD. melanogasterC. elegans
Genome BrowserNo orthologGenome BrowserNo orthologNo orthologNo ortholog
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