S. cerevisiae Gene CTF8 (YHR191C) Description and Page Index
  Description: Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion
Transcript (Including UTRs)
   Position: sacCer3 chrVIII:486,230-486,631 Size: 402 Total Exon Count: 1 Strand: -
Coding Region
   Position: sacCer3 chrVIII:486,230-486,631 Size: 402 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsProtein StructureOther SpeciesGO Annotations
Other NamesMethods
Data last updated at UCSC: 2011-08-29

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrVIII:486,230-486,631)mRNAProtein (133 aa)
Gene SorterGenome BrowserOther Species FASTASGDUniProtKB

-  Comments and Description Text from UniProtKB
  ID: CTF8_YEAST
DESCRIPTION: RecName: Full=Chromosome transmission fidelity protein 8;
FUNCTION: Essential for the fidelity of chromosome transmission. Required for the DNA replication block checkpoint. Component of the RFC-like complex CTF18-RFC which is required for efficient establishment of chromosome cohesion during S-phase and may load or unload POL30/PCNA. During a clamp loading circle, the RFC:clamp complex binds to DNA and the recognition of the double- stranded/single-stranded junction stimulates ATP hydrolysis by RFC. The complex presumably provides bipartite ATP sites in which one subunit supplies a catalytic site for hydrolysis of ATP bound to the neighboring subunit. Dissociation of RFC from the clamp leaves the clamp encircling DNA.
SUBUNIT: Component of the CTF18-RFC complex, which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5.
INTERACTION: P49956:CTF18; NbExp=5; IntAct=EBI-5216, EBI-4560; P25559:DCC1; NbExp=2; IntAct=EBI-5216, EBI-5661; P40348:RFC2; NbExp=2; IntAct=EBI-5216, EBI-14992; P38629:RFC3; NbExp=2; IntAct=EBI-5216, EBI-15000; P40339:RFC4; NbExp=2; IntAct=EBI-5216, EBI-15009; P38251:RFC5; NbExp=2; IntAct=EBI-5216, EBI-15016;
SUBCELLULAR LOCATION: Nucleus. Note=Associates with chromatin.
SIMILARITY: Belongs to the CTF8 family.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR018607 - Chromosome_trans_fidel_Ctf8

Pfam Domains:
PF09696 - Ctf8

ModBase Predicted Comparative 3D Structure on P38877
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanMouseRatZebrafishD. melanogasterC. elegans
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function
GO:0003677 DNA binding
GO:0005515 protein binding

Biological Process:
GO:0006260 DNA replication
GO:0007049 cell cycle
GO:0007064 mitotic sister chromatid cohesion
GO:0035753 maintenance of DNA trinucleotide repeats

Cellular Component:
GO:0005634 nucleus
GO:0031390 Ctf18 RFC-like complex


-  Other Names for This Gene
  UCSC ID: YHR191C
Protein: P38877 (aka CTF8_YEAST)

-  SGD Genes Methods, Credits, and Data Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.