S. cerevisiae Gene CTF8 (YHR191C) Description and Page Index
  Description: Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion
Transcript (Including UTRs)
   Position: sacCer3 chrVIII:486,230-486,631 Size: 402 Total Exon Count: 1 Strand: -
Coding Region
   Position: sacCer3 chrVIII:486,230-486,631 Size: 402 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsProtein StructureOther SpeciesGO Annotations
Other NamesMethods
Data last updated at UCSC: 2011-08-29

-  Sequence and Links to Tools and Databases
Genomic Sequence (chrVIII:486,230-486,631)mRNAProtein (133 aa)
Gene SorterGenome BrowserOther Species FASTASGDUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Chromosome transmission fidelity protein 8;
FUNCTION: Essential for the fidelity of chromosome transmission. Required for the DNA replication block checkpoint. Component of the RFC-like complex CTF18-RFC which is required for efficient establishment of chromosome cohesion during S-phase and may load or unload POL30/PCNA. During a clamp loading circle, the RFC:clamp complex binds to DNA and the recognition of the double- stranded/single-stranded junction stimulates ATP hydrolysis by RFC. The complex presumably provides bipartite ATP sites in which one subunit supplies a catalytic site for hydrolysis of ATP bound to the neighboring subunit. Dissociation of RFC from the clamp leaves the clamp encircling DNA.
SUBUNIT: Component of the CTF18-RFC complex, which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5.
INTERACTION: P49956:CTF18; NbExp=5; IntAct=EBI-5216, EBI-4560; P25559:DCC1; NbExp=2; IntAct=EBI-5216, EBI-5661; P40348:RFC2; NbExp=2; IntAct=EBI-5216, EBI-14992; P38629:RFC3; NbExp=2; IntAct=EBI-5216, EBI-15000; P40339:RFC4; NbExp=2; IntAct=EBI-5216, EBI-15009; P38251:RFC5; NbExp=2; IntAct=EBI-5216, EBI-15016;
SUBCELLULAR LOCATION: Nucleus. Note=Associates with chromatin.
SIMILARITY: Belongs to the CTF8 family.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR018607 - Chromosome_trans_fidel_Ctf8

Pfam Domains:
PF09696 - Ctf8

ModBase Predicted Comparative 3D Structure on P38877
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanMouseRatZebrafishD. melanogasterC. elegans
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function
GO:0003677 DNA binding
GO:0005515 protein binding

Biological Process:
GO:0006260 DNA replication
GO:0007049 cell cycle
GO:0007064 mitotic sister chromatid cohesion
GO:0035753 maintenance of DNA trinucleotide repeats

Cellular Component:
GO:0005634 nucleus
GO:0031390 Ctf18 RFC-like complex

-  Other Names for This Gene
Protein: P38877 (aka CTF8_YEAST)

-  SGD Genes Methods, Credits, and Data Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.