Mouse Gene Slc25a21 (uc007npj.2) Description and Page Index
  Description: mitochondrial 2-oxodicarboxylate carrier isoform
Transcript (Including UTRs)
   Position: mm9 chr12:57,813,621-58,298,459 Size: 484,839 Total Exon Count: 10 Strand: -
Coding Region
   Position: mm9 chr12:57,814,800-58,297,926 Size: 483,127 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsCTDMicroarray ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated: 2011-03-02

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:57,813,621-58,298,459)mRNA (may differ from genome)Protein (298 aa)
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-  Comments and Description Text from UniProtKB
  ID: ODC_MOUSE
DESCRIPTION: RecName: Full=Mitochondrial 2-oxodicarboxylate carrier; AltName: Full=Solute carrier family 25 member 21;
FUNCTION: Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2- oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate (By similarity).
SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity).
SIMILARITY: Belongs to the mitochondrial carrier family.
SIMILARITY: Contains 3 Solcar repeats.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from GNF1M Mouse Chip

    
     
      
       
     
    
   
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GNF Expression Atlas Data from U74b Mouse Chip

          
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -195.68533-0.367 Picture PostScript Text
3' UTR -237.111179-0.201 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR018108 - Mitochondrial_sb/sol_carrier
IPR023395 - Mt_carrier_dom

Pfam Domains:
PF00153 - Mitochondrial carrier protein

SCOP Domains:
103506 - Mitochondrial carrier

ModBase Predicted Comparative 3D Structure on Q8BZ09
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
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Protein SequenceProtein SequenceProtein SequenceProtein SequenceProtein SequenceProtein Sequence
AlignmentAlignmentAlignmentAlignmentAlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005310 dicarboxylic acid transmembrane transporter activity

Biological Process:
GO:0006835 dicarboxylic acid transport
GO:0006839 mitochondrial transport

Cellular Component:
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK167535 - Mus musculus 14 days embryo liver cDNA, RIKEN full-length enriched library, clone:I530019A21 product:solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21, full insert sequence.
AK045180 - Mus musculus 9.5 days embryo parthenogenote cDNA, RIKEN full-length enriched library, clone:B130044A15 product:MOTOCHONDRIAL OXODICARBOXYLATE CARRIER homolog [Rattus norvegicus], full insert sequence.
AK041694 - Mus musculus 3 days neonate thymus cDNA, RIKEN full-length enriched library, clone:A630030I10 product:MOTOCHONDRIAL OXODICARBOXYLATE CARRIER homolog [Rattus norvegicus], full insert sequence.
AK162379 - Mus musculus adult male epididymis cDNA, RIKEN full-length enriched library, clone:9230119I19 product:solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21, full insert sequence.
AK036988 - Mus musculus adult female vagina cDNA, RIKEN full-length enriched library, clone:9930033G19 product:MOTOCHONDRIAL OXODICARBOXYLATE CARRIER homolog [Rattus norvegicus], full insert sequence.
EU180236 - Mus musculus mitochondrial solute carrier family 25 member 21 (Slc25a21) mRNA, complete cds, alternatively spliced; nuclear gene for mitochondrial product.
BC057980 - Mus musculus solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21, mRNA (cDNA clone MGC:67702 IMAGE:5042653), complete cds.
AK044945 - Mus musculus 9.5 days embryo parthenogenote cDNA, RIKEN full-length enriched library, clone:B130014P16 product:MOTOCHONDRIAL OXODICARBOXYLATE CARRIER homolog [Rattus norvegicus], full insert sequence.
AK171801 - Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone:F830011M21 product:solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21, full insert sequence.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8BZ09 (Reactome details) participates in the following event(s):

R-MMU-372480 2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix]
R-MMU-71064 Lysine catabolism
R-MMU-6788656 Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism
R-MMU-71291 Metabolism of nitrogenous molecules
R-MMU-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: NM_172577, NP_766165, Odc, ODC_MOUSE, Q8BY72, Q8BZ09, uc007npj.1
UCSC ID: uc007npj.2
RefSeq Accession: NM_172577
Protein: Q8BZ09 (aka ODC_MOUSE)
CCDS: CCDS25925.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_172577.3
exon count: 10CDS single in 3' UTR: no RNA size: 2609
ORF size: 897CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1903.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.