Mouse Gene Cltrn (ENSMUST00000015545.9) Description and Page Index
  Description: Mus musculus collectrin, amino acid transport regulator (Cltrn), transcript variant 1, mRNA. (from RefSeq NM_020626)
Gencode Transcript: ENSMUST00000015545.9
Gencode Gene: ENSMUSG00000015401.12
Transcript (Including UTRs)
   Position: mm10 chrX:164,090,187-164,118,859 Size: 28,673 Total Exon Count: 6 Strand: +
Coding Region
   Position: mm10 chrX:164,090,273-164,118,352 Size: 28,080 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2019-09-19

-  Sequence and Links to Tools and Databases
Genomic Sequence (chrX:164,090,187-164,118,859)mRNA (may differ from genome)Protein (222 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
EnsemblEntrez GeneExonPrimerGeneCardsMGIPubMed
Stanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Collectrin; AltName: Full=Transmembrane protein 27; Flags: Precursor;
FUNCTION: Regulator of SNARE complex function. Stimulator of beta cell replication.
SUBUNIT: Homodimer. Interacts with SNAPIN. Associates with SLC6A18.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).
TISSUE SPECIFICITY: Kidney; collecting ducts. Pancreas; beta cells of islets.
PTM: Glycosylated.
PTM: The extracellular domain is cleaved and released from the cell membrane of pancreatic beta cells.
SIMILARITY: Belongs to the TMEM27 family.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -17.9086-0.208 Picture PostScript Text
3' UTR -100.20507-0.198 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001548 - Peptidase_M2

Pfam Domains:
PF16959 - Renal amino acid transporter

ModBase Predicted Comparative 3D Structure on Q9ESG4
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0008241 peptidyl-dipeptidase activity
GO:0042803 protein homodimerization activity

Biological Process:
GO:0006508 proteolysis
GO:0035543 positive regulation of SNARE complex assembly
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0045956 positive regulation of calcium ion-dependent exocytosis
GO:0051957 positive regulation of amino acid transport

Cellular Component:
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031526 brush border membrane

-  Descriptions from all associated GenBank mRNAs
  AF178085 - Mus musculus collectrin mRNA, complete cds.
AK148534 - Mus musculus adult pancreas islet cells cDNA, RIKEN full-length enriched library, clone:C820019D11 product:kidney-specific membrane protein, full insert sequence.
AK002337 - Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, clone:0610008J07 product:kidney-specific membrane protein, full insert sequence.
BC049912 - Mus musculus transmembrane protein 27, mRNA (cDNA clone MGC:54532 IMAGE:4973401), complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_020626, Nx17, Q3UFF6, Q9ESG4, Tmem27, TMM27_MOUSE, uc009uve.1
UCSC ID: uc009uve.1
RefSeq Accession: NM_020626
Protein: Q9ESG4 (aka TMM27_MOUSE)
CCDS: CCDS30517.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.