Mouse Gene Ace2 (ENSMUST00000073973.10) Description and Page Index
  Description: Mus musculus angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 (Ace2), transcript variant 2, mRNA. (from RefSeq NM_027286)
Gencode Transcript: ENSMUST00000073973.10
Gencode Gene: ENSMUSG00000015405.15
Transcript (Including UTRs)
   Position: mm10 chrX:164,140,478-164,188,420 Size: 47,943 Total Exon Count: 18 Strand: +
Coding Region
   Position: mm10 chrX:164,140,662-164,187,600 Size: 46,939 Coding Exon Count: 18 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:164,140,478-164,188,420)mRNA (may differ from genome)Protein (805 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedReactomeStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: ACE2_MOUSE
DESCRIPTION: RecName: Full=Angiotensin-converting enzyme 2; EC=3.4.17.23; AltName: Full=ACE-related carboxypeptidase; Contains: RecName: Full=Processed angiotensin-converting enzyme 2; Flags: Precursor;
FUNCTION: Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin- 13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. May have a protective role in acute lung injury.
CATALYTIC ACTIVITY: Angiotensin II + H(2)O = angiotensin-(1-7) + L-phenylalanine.
COFACTOR: Binds 1 zinc ion per subunit (By similarity).
COFACTOR: Binds 1 chloride ion per subunit (By similarity).
SUBUNIT: Weakly interacts with SARS-CoV S protein.
SUBCELLULAR LOCATION: Processed angiotensin-converting enzyme 2: Secreted (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein (By similarity).
TISSUE SPECIFICITY: Expressed in heart, kidney and forebrain (at protein level). Ubiquitously expressed, with highest levels in ileum, kidney and lung. In lung, expressed on vascular endothelial and airway epithelial cells.
INDUCTION: Down-regulated in lung after acute injury.
PTM: Proteolytic cleavage by ADAM17 generates a secreted form (By similarity).
DISRUPTION PHENOTYPE: Mice are viable and fertile, exhibit normal kidney and lung function, but show a severe reduction in cardiac contractility, and are highly sensitive to severe acute lung failure. Transgenic mice overexpressing ACE2 in the heart appear healthy but show conduction disturbances and ventricular arrhythmias which can lead to sudden death.
SEQUENCE CAUTION: Sequence=BAB40431.1; Type=Frameshift; Positions=784;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -42.70184-0.232 Picture PostScript Text
3' UTR -233.20820-0.284 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001548 - Peptidase_M2

Pfam Domains:
PF01401 - Angiotensin-converting enzyme
PF16959 - Renal amino acid transporter

SCOP Domains:
55486 - Metalloproteases ("zincins"), catalytic domain

ModBase Predicted Comparative 3D Structure on Q8R0I0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
 RGDEnsembl   
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001618 virus receptor activity
GO:0004175 endopeptidase activity
GO:0004180 carboxypeptidase activity
GO:0004181 metallocarboxypeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0008241 peptidyl-dipeptidase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

Biological Process:
GO:0003051 angiotensin-mediated drinking behavior
GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin
GO:0006508 proteolysis
GO:0015827 tryptophan transport
GO:0032800 receptor biosynthetic process
GO:0046718 viral entry into host cell
GO:0046813 receptor-mediated virion attachment to host cell
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0051957 positive regulation of amino acid transport
GO:0060452 positive regulation of cardiac muscle contraction
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:1903598 positive regulation of gap junction assembly
GO:1903779 regulation of cardiac conduction

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031526 brush border membrane


-  Descriptions from all associated GenBank mRNAs
  EF408740 - Mus musculus angiotensin converting enzyme 2 transcript variant 2 (Ace2) mRNA, complete cds, alternatively spliced.
EF408739 - Mus musculus angiotensin converting enzyme 2 transcript variant 1 (Ace2) mRNA, complete cds, alternatively spliced.
AB053181 - Mus musculus ACE2 mRNA for anigotensin-converting enzyme-related carboxypeptidase, complete cds.
AB053182 - Mus musculus ACE2 mRNA for anigotensin-converting enzyme-related carboxypeptidase, complete cds.
BC026801 - Mus musculus angiotensin I converting enzyme (peptidyl-dipeptidase A) 2, mRNA (cDNA clone MGC:25940 IMAGE:4236529), complete cds.
AK141604 - Mus musculus adult male hippocampus cDNA, RIKEN full-length enriched library, clone:C630041D11 product:angiotensin I converting enzyme (peptidyl-dipeptidase A) 2, full insert sequence.
GQ262785 - Mus musculus angiotensin I converting enzyme 2 mRNA, partial cds.
AK135357 - Mus musculus 12 days embryo female mullerian duct includes surrounding region cDNA, RIKEN full-length enriched library, clone:6820405H22 product:angiotensin I converting enzyme (peptidyl-dipeptidase A) 2, full insert sequence.
AK008530 - Mus musculus adult male small intestine cDNA, RIKEN full-length enriched library, clone:2010305L05 product:ANIGOTENSIN-CONVERTING ENZYME-RELATED CARBOXYPEPTIDASE, full insert sequence.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu04614 - Renin-angiotensin system
mmu04974 - Protein digestion and absorption

BioCarta from NCI Cancer Genome Anatomy Project
m_ace2Pathway - Angiotensin-converting enzyme 2 regulates heart function

Reactome (by CSHL, EBI, and GO)

Protein Q8R0I0 (Reactome details) participates in the following event(s):

R-MMU-2022378 ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9)
R-MMU-2022379 ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7)
R-MMU-2022377 Metabolism of Angiotensinogen to Angiotensins
R-MMU-2980736 Peptide hormone metabolism
R-MMU-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: ACE2_MOUSE, NM_027286, Q8R0I0, Q99N70, Q99N71, uc009uvg.1, uc009uvg.2
UCSC ID: uc009uvg.2
RefSeq Accession: NM_027286
Protein: Q8R0I0 (aka ACE2_MOUSE)
CCDS: CCDS30518.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.