Gene interactions and pathways from curated databases and text-mining
Fertil Steril 2000, PMID: 10973659

Effects of laparoscopic ovarian drilling on serum vascular endothelial growth factor and on insulin responses to the oral glucose tolerance test in women with polycystic ovary syndrome.

Tulandi, T; Saleh, A; Morris, D; Jacobs, H S; Payne, N N; Tan, S L

OBJECTIVE

To evaluate the serum vascular endothelial growth factor concentrations and insulin responses to the oral glucose tolerance test before and after laparoscopic ovarian drilling in women with PCOS.

METHODS

Prospective study.

METHODS

University teaching center. PATIENT(s): Twenty-seven women with clomiphene citrate-resistant polycystic ovary syndrome.

METHODS

Laparoscopic ovarian drilling.

METHODS

VEGF levels and insulin responses to OGTT before and after ovarian drilling.

RESULTS

No difference was found in VEGF levels in women with PCOS before (6.0 +/- 1.2 ng/mL) and after ovarian drilling (5.5 +/- 1.2 ng/mL). VEGF levels before and after ovarian drilling in women who conceived were, respectively, 5.9 +/- 1.0 and 5.1 +/- 0.9 ng/mL and in those who did not conceive were 6.0 +/- 1.3 and 5.7 +/- 1.2 ng/mL. No correlation was found between baseline serum insulin and VEGF levels. VEGF concentrations in women with normal ovaries (4.5 +/- 1.7 ng/mL) were significantly lower than in women with PCOS. There was no difference in glucose and insulin responses to OGTT before and after ovarian drilling.

CONCLUSIONS

VEGF levels in women with PCOS are higher than in normal women, and ovarian drilling does not affect these levels. The procedure does not change insulin responses to OGTT.

Diseases/Pathways annotated by Medline MESH: Infertility, Female, Polycystic Ovary Syndrome
Document information provided by NCBI PubMed

Text Mining Data

vascular endothelial growth factor — insulin: " Effects of laparoscopic ovarian drilling on serum vascular endothelial growth factor and on insulin responses to the oral glucose tolerance test in women with polycystic ovary syndrome "

vascular endothelial growth factor — insulin: " To evaluate the serum vascular endothelial growth factor concentrations and insulin responses to the oral glucose tolerance test before and after laparoscopic ovarian drilling in women with PCOS "

VEGF — insulin: " VEGF levels and insulin responses to OGTT before and after ovarian drilling "

Manually curated Databases

No curated data.