Gene interactions and pathways from curated databases and text-mining
Zhonghua Yan Ke Za Zhi 2004, PMID: 14989960

[Effects of high concentrations insulin on VEGF expression in cultured Müller cells].

Song, E; Wang, Yue-hui; Xu, Qi; Wang, Xin-rui; Zhu, Xiang-hong; Wu, Jia-xiang

OBJECTIVE

To investigate the effects of high concentrations of insulin on the expression of vascular endothelial growth factor (VEGF) in cultured rabbit retinal Müller cells.

METHODS

Immunocytochemistry, in situ hybridization and the ELISA method were used to study the effects of different concentrations of insulin on the expression of vascular endothelial growth factor (VEGF) in cultured rabbit retinal Müller cells qualitatively and quantitatively.

RESULTS

VEGF expression was enhanced obviously by the insulin, which regulated the expression of VEGF at the transcription level.

CONCLUSIONS

VEGF expression in cultured Müller cells can be enhanced by high concentrations of insulin. Müller cells play a potential role in the development of neovascularization of diabetic retinopathy.

Document information provided by NCBI PubMed

Text Mining Data

VEGF → insulin: " VEGF expression was enhanced obviously by the insulin , which regulated the expression of VEGF at the transcription level "

Manually curated Databases

No curated data.