Gene interactions and pathways from curated databases and text-mining
Cancer Cell 2004, PMID: 15261137

Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes.

Brugarolas, James; Kaelin, William G

The LKB1 tumor suppressor protein controls the activity of the TSC1/TSC2 tumor suppressor complex. Mutations in LKB1 cause Peutz-Jeghers syndrome (PJS), and mutations in either TSC1 or TSC2 cause tuberous sclerosis complex--two syndromes characterized by the development of hamartomas. LKB1 activation by energy deprivation activates AMPK, which in turn phosphorylates and activates TSC2. TSC2 activation results in the inactivation of mTOR, a critical regulator of protein translation. How mTOR dysregulation after inactivation of LKB1 or TSC1/2 contributes to hamartoma development is not known. However, hypoxia-inducible factor (HIF) and VEGF are regulated by mTOR and are likely to play a contributory role.

Diseases/Pathways annotated by Medline MESH: Hamartoma, Peutz-Jeghers Syndrome, Tuberous Sclerosis
Document information provided by NCBI PubMed

Text Mining Data

TSC1/TSC2 — tumor suppressor protein: " The LKB1 tumor suppressor protein controls the activity of the TSC1/TSC2 tumor suppressor complex "

TSC1/TSC2 — tumor suppressor protein: " The LKB1 tumor suppressor protein controls the activity of the TSC1/TSC2 tumor suppressor complex "

TSC2 → AMPK: " LKB1 activation by energy deprivation activates AMPK , which in turn phosphorylates and activates TSC2 "

AMPK → LKB1: " LKB1 activation by energy deprivation activates AMPK , which in turn phosphorylates and activates TSC2 "

VEGF → mTOR: " However, hypoxia-inducible factor ( HIF ) and VEGF are regulated by mTOR and are likely to play a contributory role "

Manually curated Databases

No curated data.