Gene interactions and pathways from curated databases and text-mining
Science 2008, PMID: 18787170

FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression.

Mao, Jian-Hua; Kim, Il-Jin; Wu, Di; Climent, Joan; Kang, Hio Chung; DelRosario, Reyno; Balmain, Allan

The enzyme mTOR (mammalian target of rapamycin) is a major target for therapeutic intervention to treat many human diseases, including cancer, but very little is known about the processes that control levels of mTOR protein. Here, we show that mTOR is targeted for ubiquitination and consequent degradation by binding to the tumor suppressor protein FBXW7. Human breast cancer cell lines and primary tumors showed a reciprocal relation between loss of FBXW7 and deletion or mutation of PTEN (phosphatase and tensin homolog), which also activates mTOR. Tumor cell lines harboring deletions or mutations in FBXW7 are particularly sensitive to rapamycin treatment, which suggests that loss of FBXW7 may be a biomarker for human cancers susceptible to treatment with inhibitors of the mTOR pathway.

Diseases/Pathways annotated by Medline MESH: Breast Neoplasms
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Text Mining Data

Dashed line = No text mining data

Manually curated Databases

  • IRef Biogrid Interaction: FBXW7 — MTOR (physical association, affinity chromatography technology)
In total, 1 gene pairs are associated to this article in curated databases