Gene interactions and pathways from curated databases and text-mining
Cell Biol Int 2009, PMID: 19524688

Inhibition of PKHD1 may cause S-phase entry via mTOR signaling pathway.

Zheng, Rong; Wang, Li; Fan, Junming; Zhou, Qin

Autosomal recessive polycystic kidney disease (ARPKD) is an important genetic disorder in pediatric nephrological practice. Mutation of the polycystic kidney and hepatic disease gene 1 (PKHD1) was identified as the cause of ARPKD. Rapamycin is a highly specific inhibitor of mammalian target of rapamycin (mTOR). Rapamycin exerts its biological activity by inhibiting the serine-threonine kinase mTOR, which regulates important cellular processes such as control of cell cycle, cell size, translation initiation and transcription. The ability of rapamycin to cause G1-cell cycle arrest, reduced cell growth and a reduced rate of proliferation has led to efforts to develop rapamycin and related mTOR inhibitors as anti-cystogenesis agents. Therefore, we investigated the relationship between the decreased FPC and the protein levels of mTOR and the inhibitory effects of rapamycin on the expression of mTOR, Hypoxia-inducible factor-1 alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF) in the human 293T cell line. These observations should provide an important platform for determining FPC function and the pathogenesis of ARPKD, with the targeting of mTOR signaling being exploitable as a novel therapy.

Diseases/Pathways annotated by Medline MESH: Polycystic Kidney, Autosomal Recessive
Document information provided by NCBI PubMed

Text Mining Data

vascular endothelial growth factor — mTOR: " Therefore, we investigated the relationship between the decreased FPC and the protein levels of mTOR and the inhibitory effects of rapamycin on the expression of mTOR, Hypoxia-inducible factor-1 alpha ( HIF-1alpha ) and vascular endothelial growth factor ( VEGF ) in the human 293T cell line "

Hypoxia-inducible factor-1 alpha — mTOR: " Therefore, we investigated the relationship between the decreased FPC and the protein levels of mTOR and the inhibitory effects of rapamycin on the expression of mTOR, Hypoxia-inducible factor-1 alpha ( HIF-1alpha ) and vascular endothelial growth factor ( VEGF ) in the human 293T cell line "

Manually curated Databases

No curated data.