Gene interactions and pathways from curated databases and text-mining
FEBS Lett 2009, PMID: 19619545

Ribavirin enhances interferon signaling via stimulation of mTOR and p53 activities.

Su, Wen-Cheng; Liu, Wei-Liang; Cheng, Ching-Wei; Chou, Yu-Bin; Hung, Ko-Hsuan; Huang, Wen-Hung; Wu, Chao-Liang; Li, Yuan-Tsung; Shiau, Ai-Li; Lai, Ming-Yang

Cellular mechanisms involving the enhancement of interferon (IFN) signaling by ribavirin remain poorly understood. Here, we identified a novel role of ribavirin in the communication between p53 and the mammalian target of rapamycin (mTOR) signaling. Ribavirin activates p53 by stimulating mTOR and promoting the interaction between mTOR and p53. Activated p53 stimulates the transcription of IFN regulatory factor 9 and subsequently enhances IFN signaling. Furthermore, ribavirin-induced activation of mTOR and p53 enhances IFN-dependent signaling for the IFN-alpha/ribavirin combined treatment. We conclude that ribavirin enhances activities of mTOR and p53, which may account for its antiviral and antitumor effects.

Document information provided by NCBI PubMed

Text Mining Data

Dashed line = No text mining data

Manually curated Databases

  • IRef Biogrid Interaction: RICTOR — MTOR (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: RPTOR — MTOR (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TP53 — MTOR (physical association, affinity chromatography technology)
  • IRef Intact Interaction: RPTOR — MTOR (association, anti bait coimmunoprecipitation)
  • IRef Intact Interaction: TP53 — MTOR (association, anti bait coimmunoprecipitation)
In total, 3 gene pairs are associated to this article in curated databases