Gene interactions and pathways from curated databases and text-mining
Mol Cell Neurosci 2011, PMID: 21145972

NGF activation of TrkA induces vascular endothelial growth factor expression via induction of hypoxia-inducible factor-1α.

Nakamura, Katsuya; Tan, Fei; Li, Zhijie; Thiele, Carol J

Communication between the vasculature and nervous system is important during embryogenesis but the molecular mechanisms mediating this are ill-defined. We evaluated the molecular mechanisms by which Nerve Growth Factor (NGF) and Brain-derived neurotrophic factor (BDNF) regulate VEGF production. NGF activation of TrkA causes a marked increase in VEGF secretion by neuronal cells. The NGF induced increase in VEGF is accompanied by an increase in HIF-1α. Pharmacologic inhibitors of the Trk tyrosine kinase, PI-3 kinase and mTOR paths prevent NGF stimulated increases in HIF-1α and VEGF. NGF induced increase in VEGF transcription is dependent on a hypoxia response element (HRE) in the VEGF promoter. Mutation of the HRE or siRNA mediated silencing of HIF-1α expression blocks NGF induced increases in VEGF transcription. In primary cultures of TrkA expressing neurons from dorsal root ganglion, NGF induces VEGF expression that is accompanied by increases in HIF-1α but not HIF-2α expression. In CGN neurons, BDNF induces VEGF that is dependent on induction of HIF-1α. Our study indicates that neurotrophin activation of Trk stimulates an increase in VEGF transcription that is mediated by induction of HIF-1α.

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Text Mining Data

vascular endothelial growth factor → NGF: " NGF activation of TrkA induces vascular endothelial growth factor expression via induction of hypoxia-inducible factor-1a "

vascular endothelial growth factor → TrkA: " NGF activation of TrkA induces vascular endothelial growth factor expression via induction of hypoxia-inducible factor-1a "

NGF → TrkA: " NGF activation of TrkA induces vascular endothelial growth factor expression via induction of hypoxia-inducible factor-1a "

VEGF → Brain derived neurotrophic factor (BDNF): " We evaluated the molecular mechanisms by which Nerve Growth Factor (NGF) and Brain derived neurotrophic factor (BDNF) regulate VEGF production "

VEGF → Nerve Growth Factor (NGF): " We evaluated the molecular mechanisms by which Nerve Growth Factor (NGF) and Brain derived neurotrophic factor (BDNF) regulate VEGF production "

VEGF → NGF: " NGF activation of TrkA causes a marked increase in VEGF secretion by neuronal cells "

VEGF → TrkA: " NGF activation of TrkA causes a marked increase in VEGF secretion by neuronal cells "

NGF → TrkA: " NGF activation of TrkA causes a marked increase in VEGF secretion by neuronal cells "

VEGF → NGF: " The NGF induced increase in VEGF is accompanied by an increase in HIF-1a "

VEGF → mTOR: " Pharmacologic inhibitors of the Trk tyrosine kinase, PI-3 kinase and mTOR paths prevent NGF stimulated increases in HIF-1a and VEGF "

HIF-1a → mTOR: " Pharmacologic inhibitors of the Trk tyrosine kinase, PI-3 kinase and mTOR paths prevent NGF stimulated increases in HIF-1a and VEGF "

NGF → mTOR: " Pharmacologic inhibitors of the Trk tyrosine kinase, PI-3 kinase and mTOR paths prevent NGF stimulated increases in HIF-1a and VEGF "

VEGF → NGF: " In primary cultures of TrkA expressing neurons from dorsal root ganglion, NGF induces VEGF expression that is accompanied by increases in HIF-1a but not HIF-2a expression "

BDNF → VEGF: " In CGN neurons, BDNF induces VEGF that is dependent on induction of HIF-1a "

VEGF → HIF-1a: " Our study indicates that neurotrophin activation of Trk stimulates an increase in VEGF transcription that is mediated by induction of HIF-1a "

VEGF → neurotrophin: " Our study indicates that neurotrophin activation of Trk stimulates an increase in VEGF transcription that is mediated by induction of HIF-1a "

Manually curated Databases

No curated data.