Gene interactions and pathways from curated databases and text-mining
J Clin Invest 2011, PMID: 21490404

Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy.

Wander, Seth A; Hennessy, Bryan T; Slingerland, Joyce M

Mammalian target of rapamycin (mTOR) is a PI3K-related kinase that regulates cell growth, proliferation, and survival via mTOR complex 1 (mTORC1) and mTORC2. The mTOR pathway is often aberrantly activated in cancers. While hypoxia, nutrient deprivation, and DNA damage restrain mTORC1 activity, multiple genetic events constitutively activate mTOR in cancers. Here we provide a brief overview of the signaling pathways up- and downstream of mTORC1 and -2, and discuss the insights into therapeutic anticancer targets - both those that have been tried in the clinic with limited success and those currently under clinical development - that knowledge of these pathways gives us.

Diseases/Pathways annotated by Medline MESH: Neoplasms
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Text Mining Data

mTOR → mTORC1: " While hypoxia, nutrient deprivation, and DNA damage restrain mTORC1 activity, multiple genetic events constitutively activate mTOR in cancers "

Manually curated Databases

No curated data.