Gene interactions and pathways from curated databases and text-mining
Autophagy 2011, PMID: 21521945

AMPK and mTOR coordinate the regulation of Ulk1 and mammalian autophagy initiation.

Shang, Libin; Wang, Xiaodong

Ulk1 is a serine/threonine kinase and the mammalian functional homolog of yeast Atg1. It acts at the initiation step of autophagy and forms a complex with mAtg13, FIP200 and Atg101. Assembly of this complex is independent of mTOR signaling, indicating the regulation of autophagy initiation in mammals is different from that in yeast. In a recent study, we reported that Ulk1 can be phosphorylated by mTOR and AMPK kinases. AMPK associates with Ulk1 in nutrient-dependent manner. Rapid dissociation between Ulk1 and AMPK primes cells for fast autophagy induction upon nutrient withdrawal. These studies show that both mTOR and AMPK directly regulate Ulk1 and coordinate the mammalian autophagy initiation.

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Text Mining Data

Ulk1 → mTOR: " These studies show that both mTOR and AMPK directly regulate Ulk1 and coordinate the mammalian autophagy initiation "

Ulk1 → AMPK: " These studies show that both mTOR and AMPK directly regulate Ulk1 and coordinate the mammalian autophagy initiation "

Manually curated Databases

No curated data.