Gene interactions and pathways from curated databases and text-mining
PloS one 2013, PMID: 23431403

Kinase suppressor of Ras 1 is not required for the generation of regulatory and memory T cells.

Le Borgne, Marie; Filbert, Erin L; Shaw, Andrey S

The mammalian target of rapamycin (mTOR) kinase is a critical regulator of the differentiation of helper and regulatory CD4+ T cells, as well as memory CD8+ T cells. In this study, we investigated the role of the ERK signaling pathway in regulating mTOR activation in T cells. We showed that activation of ERK following TCR engagement is required for sustained mTOR complex 1 (mTORC1) activation. Absence of kinase suppressor of Ras 1 (KSR1), a scaffold protein of the ERK signaling pathway, or inhibition of ERK resulted in decreased mTORC1 activity following T cell activation. However, KSR1-deficient mice displayed normal regulatory CD4+ T cell development, as well as normal memory CD8+ T cell responses to LCMV and Listeria monocytogenes infection. These data indicate that despite its role in mTORC1 activation, KSR1 is not required in vivo for mTOR-dependent T cell differentiation.

Diseases/Pathways annotated by Medline MESH: Listeriosis, MAP Kinase Signaling System
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Text Mining Data

mTOR complex 1 (mTORC1) → ERK: " We showed that activation of ERK following TCR engagement is required for sustained mTOR complex 1 (mTORC1) activation "

mTORC1 ⊣ ERK: " Absence of kinase suppressor of Ras 1 (KSR1), a scaffold protein of the ERK signaling pathway, or inhibition of ERK resulted in decreased mTORC1 activity following T cell activation "

mTORC1 ⊣ kinase suppressor of Ras 1 (KSR1): " Absence of kinase suppressor of Ras 1 (KSR1) , a scaffold protein of the ERK signaling pathway, or inhibition of ERK resulted in decreased mTORC1 activity following T cell activation "

ERK ⊣ kinase suppressor of Ras 1 (KSR1): " Absence of kinase suppressor of Ras 1 (KSR1) , a scaffold protein of the ERK signaling pathway, or inhibition of ERK resulted in decreased mTORC1 activity following T cell activation "

Manually curated Databases

No curated data.