Gene interactions and pathways from curated databases and text-mining

◀ Back to IL1B

A2M — IL1B

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Bode et al., J Immunol 2001 : The inhibitory effect of IL-1 beta on IL-6 induced alpha 2-macroglobulin expression is due to activation of NF-kappa B ... In this study, it is analyzed how IL-1beta inhibits IL-6 induced transcriptional activation of the alpha(2)-macroglobulin promoter ... The observation that inhibition of IL-6 induced transcriptional activation of this promoter by IL-1beta is reversed by cotransfection with I-kappaBalpha provides evidence that NF-kappaB activation by IL-1beta is responsible for inhibition of IL-6 mediated trans activation of the alpha(2)-macroglobulin gene
Andus et al., Eur J Biochem 1988 : The stimulation of alpha 2-macroglobulin and cysteine proteinase inhibitor synthesis by interleukin-6 was inhibited by interleukin-1 beta in a dose dependent manner
Warburton et al., FEBS Lett 1993 : Interleukin-1 beta , interleukin-6 and transforming growth factor-beta synergize with hydrocortisone, increasing the synthesis of alpha 2-macroglobulin 2- to 4-fold, although they have no effect in the absence of hydrocortisone