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AANAT — MAPK12
Text-mined interactions from Literome
Man et al., Endocrinology 2004
:
In this study we investigated whether p38 (
MAPK )
played a role in the adrenergic regulation of
arylalkylamine-N-acetyltransferase ( AA-NAT ) induction and melatonin ( MT ) synthesis ... Cotreatment with SB202190, a selective p38 (
MAPK ) inhibitor, although having no effect on AA-NAT activity or protein level 3 h after NE treatment,
caused a sustained increase in
AA-NAT activity and protein level after 6 h of NE treatment
Ho et al., Mol Cell Endocrinol 2006
:
Studies with selective MAPK inhibitors reveal a modulating effect of MAPKs on arylalkylamine-N-acetyltransferse ( AA-NAT ) activity, with
involvement of
p42/44MAPK in the induction of
AA-NAT and p38MAPK participating in the amplitude and duration of the AA-NAT response ... These
effects of
p42/44MAPK and p38MAPK on
AA-NAT activity match their timing of activation