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ADAM12 — EGFR

Text-mined interactions from Literome

Tanida et al., Gastroenterology 2004 (Stomach Neoplasms) : Although this EGFR transactivation reportedly requires a disintegrin and metalloproteinase ( ADAM ) that sheds the ectodomain of EGFR ligands, the detailed mechanisms are still unknown
Itoh et al., Cytokine 2005 (Carcinoma...) : IL-8 transiently induced EGFR tyrosine phosphorylation after 5-90 min and this was completely inhibited by ADAM inhibitor
Joh et al., Dig Dis Sci 2005 : Helicobacter pylori stimulated interleukin-8 (IL-8) promotes cell proliferation through transactivation of epidermal growth factor receptor (EGFR) by disintegrin and metalloproteinase ( ADAM ) activation
Ohtsu et al., Am J Physiol Cell Physiol 2006 : The major focus of the review will be on the possible upstream mechanisms of ADAM activation by GPCRs as well as downstream signal transduction and the pathophysiological significances of ADAM dependent EGFR transactivation
Yin et al., Invest Ophthalmol Vis Sci 2009 : Taken together, our data suggest that in addition to functioning as an EGFR downstream effector, ERK1/2 also mediates ADAM dependent HB-EGF shedding and subsequent EGFR transactivation in response to a variety of stimuli, including wounding and GPCR ligands
Bakken et al., J Vasc Surg 2009 : To determine the role of ADAM in EGFR transactivation by ATF in human vascular smooth muscle cells ( VSMC ) during cell migration
Kasina et al., Cell Prolif 2009 : ADAM mediated amphiregulin shedding and EGFR transactivation ... These data also show that CXCL12 mediated cellular proliferation requires EGFR transactivation in a Src- and ADAM dependent manner in non transformed prostate epithelial cells
Takaguri et al., Hypertension 2011 (Carotid Artery Injuries...) : In conclusion, ADAM17 activation is involved in epidermal growth factor receptor activation and subsequent neointimal hyperplasia after vascular injury
Sanchez-Guerrero et al., PloS one 2012 : This study reports for the first time that Egr-1 induction by IL-1beta involves EGFR and MMP/ADAM dependent EGFR phosphorylation
Li et al., Breast Cancer Res Treat 2012 (Breast Neoplasms...) : We further demonstrate that ectopic expression of ADAM12L increased EGFR phosphorylation in a mouse intraductal xenograft model of early breast cancer